product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Slit2 (aa 26-900) Protein, CF
catalog :
5444-SL-050
quantity :
50 ug
price :
540 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Hoving J, Harford Wright E, Wingfield Digby P, Cattin A, Campana M, Power A, et al. N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion. elife. 2024;13: pubmed publisher
Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, et al. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 2019;10:2350 pubmed publisher
Pilling D, Chinea L, Consalvo K, Gomer R. Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils. J Immunol. 2019;202:239-248 pubmed publisher
Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli F. Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018;9:5082 pubmed publisher
Aleksandrova N, Gutsche I, Kandiah E, Avilov S, Petoukhov M, Seiradake E, et al. Robo1 Forms a Compact Dimer-of-Dimers Assembly. Structure. 2018;26:320-328.e4 pubmed publisher
Erdogan B, Cammarata G, Lee E, Pratt B, Francl A, Rutherford E, et al. The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural Dev. 2017;12:3 pubmed publisher
Zhang F, Prahst C, Mathivet T, Pibouin Fragner L, Zhang J, Genet G, et al. The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nat Commun. 2016;7:13517 pubmed publisher
Pilling D, Zheng Z, Vakil V, Gomer R. Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proc Natl Acad Sci U S A. 2014;111:18291-6 pubmed publisher
Yeh M, Gonda Y, Mommersteeg M, Barber M, Ypsilanti A, Hanashima C, et al. Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014;34:5717-31 pubmed publisher
Guijarro Muñoz I, Cuesta A, Alvarez Cienfuegos A, Geng J, Alvarez Vallina L, Sanz L. The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. Exp Cell Res. 2012;318:371-8 pubmed publisher
Mulik S, Sharma S, Suryawanshi A, Veiga Parga T, Reddy P, Rajasagi N, et al. Activation of endothelial roundabout receptor 4 reduces the severity of virus-induced keratitis. J Immunol. 2011;186:7195-204 pubmed publisher
Brantley Sieders D, Dunaway C, Rao M, Short S, Hwang Y, Gao Y, et al. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res. 2011;71:976-87 pubmed publisher
Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher
product information
master code :
5444-SL
SKU :
5444-SL-050
product name :
Recombinant Mouse Slit2 (aa 26-900) Protein, CF
unit size :
50 ug
description :
The Recombinant Mouse Slit2 (aa 26-900) Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse Slit2 (aa 26-900) Protein, CF has been validated for the following applications: Bioactivity.
target :
Slit2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MOPS and NaCl.
conjugate :
Unconjugated
purity :
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
105-115 kDa, reducing conditions
theoretical molecular weight :
99.7 kDa
gene symbol :
Slit2
details of functionality :
Measured by its ability to enhance neurite outgrowth of dissociated E13 chick embryonic dorsal root ganglia (DRG) neurons. Recombinant Mouse Slit2 immobilized at 3-12 ╡g/mL, is able to significantly induce neurite outgrowth.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q9R1B9
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived mouse Slit2 protein Gln26-Gln900, with a C-terminal 10-His tag
source short :
CHO
USD :
540 USD
alt names :
FLJ14420, SLIL3, slit (Drosophila) homolog 2, slit homolog 2 (Drosophila), slit homolog 2 protein, Slit-2SLIL3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.