Recombinant Mouse Slit2 (aa 26-900) Protein, CF | R&D Systems 5444-SL-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Slit2 (aa 26-900) Protein, CF

catalog :

5444-SL-050

quantity :

50 ug

price :

540 USD

citations: 13

Reference
Hoving J, Harford Wright E, Wingfield Digby P, Cattin A, Campana M, Power A, et al. N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion. elife. 2024;13: pubmed publisher
Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, et al. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 2019;10:2350 pubmed publisher
Pilling D, Chinea L, Consalvo K, Gomer R. Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils. J Immunol. 2019;202:239-248 pubmed publisher
Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli F. Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018;9:5082 pubmed publisher
Aleksandrova N, Gutsche I, Kandiah E, Avilov S, Petoukhov M, Seiradake E, et al. Robo1 Forms a Compact Dimer-of-Dimers Assembly. Structure. 2018;26:320-328.e4 pubmed publisher
Erdogan B, Cammarata G, Lee E, Pratt B, Francl A, Rutherford E, et al. The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural Dev. 2017;12:3 pubmed publisher
Zhang F, Prahst C, Mathivet T, Pibouin Fragner L, Zhang J, Genet G, et al. The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nat Commun. 2016;7:13517 pubmed publisher
Pilling D, Zheng Z, Vakil V, Gomer R. Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proc Natl Acad Sci U S A. 2014;111:18291-6 pubmed publisher
Yeh M, Gonda Y, Mommersteeg M, Barber M, Ypsilanti A, Hanashima C, et al. Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014;34:5717-31 pubmed publisher
Guijarro Muñoz I, Cuesta A, Alvarez Cienfuegos A, Geng J, Alvarez Vallina L, Sanz L. The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. Exp Cell Res. 2012;318:371-8 pubmed publisher
Mulik S, Sharma S, Suryawanshi A, Veiga Parga T, Reddy P, Rajasagi N, et al. Activation of endothelial roundabout receptor 4 reduces the severity of virus-induced keratitis. J Immunol. 2011;186:7195-204 pubmed publisher
Brantley Sieders D, Dunaway C, Rao M, Short S, Hwang Y, Gao Y, et al. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res. 2011;71:976-87 pubmed publisher
Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher

product information

master code :

5444-SL

SKU :

5444-SL-050

product name :

Recombinant Mouse Slit2 (aa 26-900) Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse Slit2 (aa 26-900) Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse Slit2 (aa 26-900) Protein, CF has been validated for the following applications: Bioactivity.

target :

Slit2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in MOPS and NaCl.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

105-115 kDa, reducing conditions

theoretical molecular weight :

99.7 kDa

gene symbol :

Slit2

details of functionality :

Measured by its ability to enhance neurite outgrowth of dissociated E13 chick embryonic dorsal root ganglia (DRG) neurons. Recombinant Mouse Slit2 immobilized at 3-12 ╡g/mL, is able to significantly induce neurite outgrowth.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9R1B9

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived mouse Slit2 protein Gln26-Gln900, with a C-terminal 10-His tag

source short :

CHO

USD :

540 USD

alt names :

FLJ14420, SLIL3, slit (Drosophila) homolog 2, slit homolog 2 (Drosophila), slit homolog 2 protein, Slit-2SLIL3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.