Recombinant Human Integrin alpha 4 beta 7 Protein, CF | R&D Systems 5397-A3-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha 4 beta 7 Protein, CF

catalog :

5397-A3-050

quantity :

50 ug

price :

458 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Veisman I, Barzilay O, Bruckmayer L, Haj Natour O, Kopylov U, Eliakim R, et al. Association of Infliximab and Vedolizumab Trough Levels with Reported Rates of Adverse Events: A Cross-Sectional Study. J Clin Med. 2021;10: pubmed publisher
Myint P, Ito A, Appiah M, Obeng G, Darkwah S, Kawamoto E, et al. Irisin supports integrin-mediated cell adhesion of lymphocytes. Biochem Biophys Rep. 2021;26:100977 pubmed publisher
Karpova D, Rettig M, Ritchey J, Cancilla D, Christ S, Gehrs L, et al. Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells. J Clin Invest. 2019;129:2745-2759 pubmed publisher
Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, et al. Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7. PLoS Pathog. 2018;14:e1007278 pubmed publisher
Caldwell J, Collins M, Kemme K, Sherrill J, Wen T, Rochman M, et al. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal Immunol. 2017;10:1190-1201 pubmed publisher
Guerra Perez N, Frank I, Veglia F, Aravantinou M, Goode D, Blanchard J, et al. Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection. J Immunol. 2015;194:2415-23 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

5397-A3

SKU :

5397-A3-050

product name :

Recombinant Human Integrin alpha 4 beta 7 Protein, CF

Description :

The Recombinant Human Integrin alpha 4 beta 7 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha 4 beta 7 Protein, CF has been validated for the following applications: Bioactivity.

target :

Integrin alpha 4 beta 7/LPAM-1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and MgCl2.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

130-155 kDa and 100-130 kDa, under reducing conditions.

theoretical molecular weight :

112.8 kDa (Integrin alpha 4) 84.7 kDa (Integrin beta 7)

gene symbol :

ITGA4

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of CHO Chinese hamster ovary cells transfected with VCAM-1. When 5 x 104 cells per well are added to Recombinant Human Integrin alpha 4/beta 7/LPAM-1 coated plates (10 µg/mL, 100 µL/well), approximately 50-80% will adhere after 60 minutes at 37 °C.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P13612 (Integrin a4); P26010 (Integrin ss7)

applications :

Bioactivity

source :

CHO-derived Recombinant Human Integrin alpha 4 beta 7 Protein

USD :

458 USD

alt names :

269C wild type, CD49 antigen-like family member D, CD49d, CD49d antigen, CD49d/beta7, CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor, IA4, integrin alpha 4, integrin alpha-4, integrin alpha-4 subunit, Integrin alpha-IV, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor), LPAM1, LPAM-1, MGC90518, very late activation protein 4 receptor, alpha 4 subunit, VLA-4 subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage