This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human sFRP-1 Protein, CF
catalog :
5396-SF
quantity :
25 ug
price :
329 USD
citations: 13
Reference
Cho S, Kuo I, Lu P, Tzeng H, Lai W, Su W, et al. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness. Cell Death Dis. 2018;9:868 pubmed publisher
Hawkshaw N, Hardman J, Haslam I, Shahmalak A, Gilhar A, Lim X, et al. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biol. 2018;16:e2003705 pubmed publisher
McLeod F, Bossio A, Marzo A, Ciani L, Sibilla S, Hannan S, et al. Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors. Cell Rep. 2018;23:1060-1071 pubmed publisher
Steinfeld J, Steinfeld I, Bausch A, Coronato N, Hampel M, Depner H, et al. BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling. Biol Open. 2017;6:979-992 pubmed publisher
Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, et al. Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells. Biochem Biophys Res Commun. 2017;487:653-659 pubmed publisher
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, et al. A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017;40:439-452.e4 pubmed publisher
Schwafertz C, Schinner S, Kühn M, Haase M, Asmus A, Mülders Opgenoorth B, et al. Endothelial cells regulate ?-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor. Mol Cell Endocrinol. 2017;441:108-115 pubmed publisher
Koziński K, Jazurek M, Dobrzyn P, Janikiewicz J, Kolczyńska K, Gajda A, et al. Adipose- and muscle-derived Wnts trigger pancreatic ?-cell adaptation to systemic insulin resistance. Sci Rep. 2016;6:31553 pubmed publisher
Arensman M, Kovochich A, Kulikauskas R, Lay A, Yang P, Li X, et al. WNT7B mediates autocrine Wnt/?-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene. 2014;33:899-908 pubmed publisher
Dawes L, Sugiyama Y, Tanedo A, Lovicu F, McAvoy J. Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci. 2013;54:1582-90 pubmed publisher
Patel N, Sharpe P, Miletich I. Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev Biol. 2011;358:156-67 pubmed publisher
Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell. 2011;145:926-40 pubmed publisher
Blakely B, Bye C, Fernando C, Horne M, Macheda M, Stacker S, et al. Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE. 2011;6:e18373 pubmed publisher
product information
brand :
R&D Systems
master code :
5396-SF
SKU :
5396-SF-025
product name :
Recombinant Human sFRP-1 Protein, CF
description :
The Recombinant Human sFRP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human sFRP-1 Protein, CF has been validated for the following applications: Bioactivity.
target :
sFRP-1
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Phosphate and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
33-40 kDa, reducing conditions
theoretical molecular weight :
32.6 kDa
gene symbol :
SFRP1
details of functionality :
Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Ko, L. et al . (2002) Exp. Cell Res. 280 :280. The ED50 for this effect is 0.15-0.75 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
5396-SF
accessionNumbers :
AAB70793
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human sFRP-1 protein Ser32-Lys314
2020 USD :
329
2021 USD :
329 USD
alt names :
FRP1, FRP-1FrzA, FRPSARP-2, FrzA, SARP-2, SARP2sFRP-1, Secreted apoptosis-related protein 2, secreted frizzled-related protein 1, sFRP1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.