Recombinant Human sFRP-1 Protein, CF | R&D Systems 5396-SF-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human sFRP-1 Protein, CF

catalog :

5396-SF-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 15

Reference
Jeffrey D, Pires Da Silva J, Garcia A, Jiang X, Karimpour Fard A, Toni L, et al. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021;6: pubmed publisher
Park Y, Lofton M, Li D, Rasin M. Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs. Cells. 2021;10: pubmed publisher
Cho S, Kuo I, Lu P, Tzeng H, Lai W, Su W, et al. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness. Cell Death Dis. 2018;9:868 pubmed publisher
Hawkshaw N, Hardman J, Haslam I, Shahmalak A, Gilhar A, Lim X, et al. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biol. 2018;16:e2003705 pubmed publisher
McLeod F, Bossio A, Marzo A, Ciani L, Sibilla S, Hannan S, et al. Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors. Cell Rep. 2018;23:1060-1071 pubmed publisher
Steinfeld J, Steinfeld I, Bausch A, Coronato N, Hampel M, Depner H, et al. BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling. Biol Open. 2017;6:979-992 pubmed publisher
Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, et al. Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells. Biochem Biophys Res Commun. 2017;487:653-659 pubmed publisher
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, et al. A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017;40:439-452.e4 pubmed publisher
Schwafertz C, Schinner S, Kühn M, Haase M, Asmus A, Mülders Opgenoorth B, et al. Endothelial cells regulate ?-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor. Mol Cell Endocrinol. 2017;441:108-115 pubmed publisher
Koziński K, Jazurek M, Dobrzyn P, Janikiewicz J, Kolczyńska K, Gajda A, et al. Adipose- and muscle-derived Wnts trigger pancreatic ?-cell adaptation to systemic insulin resistance. Sci Rep. 2016;6:31553 pubmed publisher
Arensman M, Kovochich A, Kulikauskas R, Lay A, Yang P, Li X, et al. WNT7B mediates autocrine Wnt/?-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene. 2014;33:899-908 pubmed publisher
Dawes L, Sugiyama Y, Tanedo A, Lovicu F, McAvoy J. Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci. 2013;54:1582-90 pubmed publisher
Patel N, Sharpe P, Miletich I. Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev Biol. 2011;358:156-67 pubmed publisher
Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell. 2011;145:926-40 pubmed publisher
Blakely B, Bye C, Fernando C, Horne M, Macheda M, Stacker S, et al. Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE. 2011;6:e18373 pubmed publisher

product information

master code :

5396-SF

SKU :

5396-SF-025

product name :

Recombinant Human sFRP-1 Protein, CF

unit size :

25 ug

description :

The Recombinant Human sFRP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human sFRP-1 Protein, CF has been validated for the following applications: Bioactivity.

target :

sFRP-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Phosphate and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

33-40 kDa, reducing conditions

theoretical molecular weight :

32.6 kDa

gene symbol :

SFRP1

details of functionality :

Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Ko, L. et al . (2002) Exp. Cell Res. 280 :280. The ED50 for this effect is 0.15-0.75 ╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAB70793

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human sFRP-1 protein Ser32-Lys314

source short :

NS0

USD :

400 USD

alt names :

FRP1, FRP-1FrzA, FRPSARP-2, FrzA, SARP-2, SARP2sFRP-1, Secreted apoptosis-related protein 2, secreted frizzled-related protein 1, sFRP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage