Recombinant Human LRP-1 Cluster IV Fc Chimera Protein, CF | R&D Systems 5395-L4B-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human LRP-1 Cluster IV Fc Chimera Protein, CF

catalog :

5395-L4B-050

quantity :

50 ug

price :

540 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Sakamoto K. Generation of KS-487 as a novel LRP1-binding cyclic peptide with higher affinity, higher stability and BBB permeability. Biochem Biophys Rep. 2022;32:101367 pubmed publisher
Sakamoto K, Shinohara T, Adachi Y, Asami T, Ohtaki T. A novel LRP1-binding peptide L57 that crosses the blood brain barrier. Biochem Biophys Rep. 2017;12:135-139 pubmed publisher
Young P, Migliorini M, Strickland D. Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE. J Biol Chem. 2016;291:26035-26044 pubmed
Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, et al. Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities. PLoS ONE. 2014;9:e103839 pubmed publisher
Schorch B, Song S, van Diemen F, Bock H, May P, Herz J, et al. LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci U S A. 2014;111:6431-6 pubmed publisher
Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, et al. A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. Arterioscler Thromb Vasc Biol. 2013;33:935-42 pubmed publisher

product information

master code :

5395-L4B

SKU :

5395-L4B-050

product name :

Recombinant Human LRP-1 Cluster IV Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human LRP-1 Cluster IV Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human LRP-1 Cluster IV Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

LRP-1 Cluster IV

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

100-120 kDa, under reducing conditions.

theoretical molecular weight :

76.7 kDa

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human LRP-1 Cluster IV Fc Chimera (Catalog # 5395-L4B) is immobilized at 50 ng/mL (100 ╡L/well), Recombinant Human LRPAP (Catalog # 4296-LR ) binds with an ED50 of 0.0250-0.350 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q07954.2

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human LRP-1 Cluster IV protein Human LRP1-C4 (Ser3332-Asp3779) Accession # Q07954.2 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

CHO

USD :

540 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage