Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein, CF | R&D Systems 539-IR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein, CF

catalog :

539-IR-100

quantity :

100 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Álvarez Izquierdo M, Pérez Crespo M, Esteban J, Muñoz Antoli C, Toledo R. Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses. Parasit Vectors. 2020;13:608 pubmed publisher
Lee G, Brandt E, Xiao C, Gibson A, Le Cras T, Brown L, et al. Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma. PLoS ONE. 2013;8:e60632 pubmed publisher
Nakashima H, Terabe M, Berzofsky J, Husain S, Puri R. A novel combination immunotherapy for cancer by IL-13RÎ±2-targeted DNA vaccine and immunotoxin in murine tumor models. J Immunol. 2011;187:4935-46 pubmed publisher
Deepak P, Acharya A. Interleukin-13 induces T helper type 2 immune responses in OVA-immunized BALB/c mice bearing a T cell lymphoma. Scand J Immunol. 2012;75:85-95 pubmed publisher
Deepak P, Kumar S, Kishore D, Acharya A. IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma. Int Immunol. 2010;22:53-63 pubmed publisher
Chen W, Tabata Y, Gibson A, Daines M, Warrier M, Wills Karp M, et al. Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo. J Allergy Clin Immunol. 2008;122:625-32 pubmed publisher
Matsumoto K, Fukuyama S, Eguchi Tsuda M, Nakano T, Matsumoto T, Matsumura M, et al. B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem Biophys Res Commun. 2008;365:170-5 pubmed
Wilson M, Elnekave E, Mentink Kane M, Hodges M, Pesce J, Ramalingam T, et al. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest. 2007;117:2941-51 pubmed
Hayashi N, Yoshimoto T, Izuhara K, Matsui K, Tanaka T, Nakanishi K. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc Natl Acad Sci U S A. 2007;104:14765-70 pubmed
Kawashima R, Kawamura Y, Kato R, Mizutani N, Toyama Sorimachi N, Dohi T. IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Gastroenterology. 2006;131:130-41 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

539-IR

SKU :

539-IR-100

product name :

Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein, CF

Description :

The Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-13 R alpha 2

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

85-90 kDa, reducing conditions

theoretical molecular weight :

63 kDa (monomer)

gene symbol :

Il13ra2

details of functionality :

Measured by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.01-0.03 µg/mL in the presence of 8 ng/mL of recombinant mouse IL-13.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O88786

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse IL-13 R alpha 2 Fc Chimera Protein

USD :

423 USD

alt names :

cancer/testis antigen 19, CD213a2, CD213a2 antigen, CT19, IL-13 receptor subunit alpha-2, IL13BP, IL13R, IL-13R, IL13R alpha 2, IL-13R subunit alpha-2, IL13RA2, IL-13RA2, IL-13R-alpha-2, interleukin 13 binding protein, interleukin 13 receptor alpha 2 chain, interleukin 13 receptor, alpha 2, interleukin-13 receptor subunit alpha-2, Interleukin-13-binding protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage