product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat MAG/Siglec-4a Fc Chimera Protein, CF
catalog :
538-MG-100
quantity :
100 ug
price :
468 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Pi W, Li C, Zhang M, Zhang W, Zhang P. Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection. Neural Regen Res. 2022;17:1343-1347 pubmed publisher
Fern ndez Su rez D, Krapacher F, Andersson A, Ib ez C, Kisiswa L. MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary. Cell Death Dis. 2019;10:732 pubmed publisher
Wang T, Li B, Wang Z, Yuan X, Chen C, Zhang Y, et al. miR-155-5p Promotes Dorsal Root Ganglion Neuron Axonal Growth in an Inhibitory Microenvironment via the cAMP/PKA Pathway. Int J Biol Sci. 2019;15:1557-1570 pubmed publisher
Liu F, Gao M, Bai J, Wang Y, Li X. Inhibition of neurite outgrowth using commercial myelin associated glycoprotein-Fc in neuro-2a cells. Neural Regen Res. 2018;13:1893-1899 pubmed publisher
Wong V, Picci C, Swift M, Levinson M, Willis D, Langley B. α-Tubulin Acetyltransferase Is a Novel Target Mediating Neurite Growth Inhibitory Effects of Chondroitin Sulfate Proteoglycans and Myelin-Associated Glycoprotein. Eneuro. 2018;5: pubmed publisher
Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K. The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor. J Neurosci. 2018;38:2589-2604 pubmed publisher
Peterson S, Nguyen H, Mendez O, Anderson A. Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo. J Neurosci. 2015;35:4332-49 pubmed publisher
Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, et al. LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand. Mol Cell Neurosci. 2014;61:211-8 pubmed publisher
Carlstrom L, Hines J, Henle S, Henley J. Bidirectional remodeling of ?1-integrin adhesions during chemotropic regulation of nerve growth. BMC Biol. 2011;9:82 pubmed publisher
Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, et al. Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells. J Biol Chem. 2011;286:25739-47 pubmed publisher
Robak L, Venkatesh K, Lee H, Raiker S, Duan Y, Lee Osbourne J, et al. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. J Neurosci. 2009;29:5768-83 pubmed publisher
Williams G, Wood A, Williams E, Gao Y, Mercado M, Katz A, et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008;283:16641-52 pubmed publisher
Lee H, Raiker S, Venkatesh K, Geary R, Robak L, Zhang Y, et al. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci. 2008;28:2753-65 pubmed publisher
Milward E, Kim K, Szklarczyk A, Nguyen T, Melli G, Nayak M, et al. Cleavage of myelin associated glycoprotein by matrix metalloproteinases. J Neuroimmunol. 2008;193:140-8 pubmed
Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, et al. IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway. Biochem Biophys Res Commun. 2008;365:375-80 pubmed
Willis D, van Niekerk E, Sasaki Y, Mesngon M, Merianda T, Williams G, et al. Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs. J Cell Biol. 2007;178:965-80 pubmed
Wright K, El Masri W, Osman A, Roberts S, Chamberlain G, Ashton B, et al. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. Biochem Biophys Res Commun. 2007;354:559-66 pubmed
Hasegawa Y, Fujitani M, Hata K, Tohyama M, Yamagishi S, Yamashita T. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. J Neurosci. 2004;24:6826-32 pubmed
Wong S, Henley J, Kanning K, Huang K, Bothwell M, Poo M. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci. 2002;5:1302-8 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
538-MG
SKU :
538-MG-100
product name :
Recombinant Rat MAG/Siglec-4a Fc Chimera Protein, CF
description :
The Recombinant Rat MAG/Siglec-4a Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat MAG/Siglec-4a Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
MAG/Siglec-4a
unit size :
100 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Rat
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
120 kDa, reducing conditions
theoretical molecular weight :
81 kDa (monomer)
gene symbol :
Mag
details of functionality :
Measured by its ability to inhibit neurite outgrowth of dissociated E13 chick embryonic dorsal root ganglia (DRG) neurons. Able to significantly inhibit neurite outgrowth when immobilized as a 3 µL droplet containing 400 ng on a nitrocellulose-coated microplate.
endotoxin note :
<0.1 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P07722
applications :
Bioactivity
product keywords :
538-MG, rrMAG/Fc, rMAG, carrier-free, carrier free, 538MG, Siglec4a, Siglec 4a, Siglec-4
source :
NS0-derived Recombinant Rat MAG/Siglec-4a Fc Chimera Protein, CF
USD :
458
USD 2025 :
468 USD
alt names :
GMAsialic acid binding Ig-like lectin 4A, myelin associated glycoprotein, myelin-associated glycoprotein, sialic acid-binding immunoglobulin-like lectin 4A, Siglec4a, SIGLEC-4A, S-MAG
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.