Jang H, Kim S, Park K, Kim J. Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium. Cell Death Dis. 2023;14:334 pubmed publisher

Mao Q, Deng M, Zhao J, Zhou D, Tong W, Xu S, et al. Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Klotho in coronary atherosclerotic disease. Mech Ageing Dev. 2023;211:111789 pubmed publisher

Olejnik A, Krzywonos Zawadzka A, Banaszkiewicz M, Bil Lula I. Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes. Int J Mol Sci. 2022;23: pubmed publisher

Li L, Liu W, Mao Q, Zhou D, Ai K, Zheng W, et al. Klotho Ameliorates Vascular Calcification via Promoting Autophagy. Oxid Med Cell Longev. 2022;2022:7192507 pubmed publisher

Du C, Wang X, Wu Y, Liao W, Xiong J, Zhu Y, et al. Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance. Cell Rep. 2022;38:110392 pubmed publisher

Suk Kang J, Son S, Lee J, Lee S, Jeong A, Lee E, et al. Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy. PLoS ONE. 2021;16:e0250666 pubmed publisher

Jadhav S, Tripathi S, Chandrekar A, Waikar S, Hsiao L. A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasma. PLoS ONE. 2021;16:e0245614 pubmed publisher

Miao J, Huang J, Luo C, Ye H, Ling X, Wu Q, et al. Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Physiol Rep. 2021;9:e14696 pubmed publisher

Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, et al. Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants. Sci Rep. 2020;10:12368 pubmed publisher

Kawarazaki W, Mizuno R, Nishimoto M, Ayuzawa N, Hirohama D, Ueda K, et al. Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. J Clin Invest. 2020;130:4152-4166 pubmed publisher

Zhang Z, Nian Q, Chen G, Cui S, Han Y, Zhang J. Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis. Oxid Med Cell Longev. 2020;2020:1854206 pubmed publisher

Olejnik A, Krzywonos Zawadzka A, Banaszkiewicz M, Bil Lula I. Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury. J Cell Mol Med. 2020;24:6448-6458 pubmed publisher

The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton D, et al. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020;9: pubmed publisher

Grange C, Papadimitriou E, Dimuccio V, Pastorino C, Molina J, O Kelly R, et al. Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model. Mol Ther. 2020;28:490-502 pubmed publisher

Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, et al. Wnt/β-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019;18:e13004 pubmed publisher

Sahu A, Mamiya H, Shinde S, Cheikhi A, Winter L, Vo N, et al. Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. Nat Commun. 2018;9:4859 pubmed publisher

Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh Lamin K, Pasmanik Chor M, et al. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019;38:794-807 pubmed publisher

Lim S, Jin L, Luo K, Jin J, Shin Y, Hong S, et al. Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. Cell Death Dis. 2017;8:e2972 pubmed publisher

Yao Y, Wang Y, Zhang Y, Liu C. Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways. Lipids Health Dis. 2017;16:77 pubmed publisher

Behera R, Kaur A, Webster M, Kim S, Ndoye A, Kugel C, et al. Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017;23:3181-3190 pubmed publisher

Dalton G, An S, Al Juboori S, Nischan N, Yoon J, Dobrinskikh E, et al. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling. Proc Natl Acad Sci U S A. 2017;114:752-757 pubmed publisher

Shahmoon S, Rubinfeld H, Wolf I, Cohen Z, Hadani M, Shimon I, et al. The aging suppressor klotho: a potential regulator of growth hormone secretion. Am J Physiol Endocrinol Metab. 2014;307:E326-34 pubmed publisher

Kim H, Chang H, Han S, Lee M, Jung J, An S, et al. Epigallocatechin-3-O-(3-O-methyl)-gallate-induced differentiation of human keratinocytes involves klotho-mediated regulation of protein kinase-cAMP responsive element-binding protein signaling. Int J Mol Sci. 2014;15:5749-61 pubmed publisher

Six I, Okazaki H, Gross P, Cagnard J, Boudot C, Maizel J, et al. Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium. PLoS ONE. 2014;9:e93423 pubmed publisher

Leunissen E, Nair A, Bull C, Lefeber D, van Delft F, Bindels R, et al. The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase. J Biol Chem. 2013;288:29238-46 pubmed publisher

Seiler S, Wen M, Roth H, Fehrenz M, Flügge F, Herath E, et al. Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease. Kidney Int. 2013;83:121-8 pubmed publisher