product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF
catalog :
532-R2-050
quantity :
50 ug
price :
470 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Kissick H, Ireland D, Greay S, Beilharz M. Mechanisms of immune suppression exerted by regulatory T-cells in subcutaneous AE17 murine mesothelioma. J Interferon Cytokine Res. 2010;30:829-34 pubmed publisher
Horan G, Wood S, Ona V, Li D, Lukashev M, Weinreb P, et al. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med. 2008;177:56-65 pubmed
Close J, Gumuscu B, Reh T. Retinal neurons regulate proliferation of postnatal progenitors and Müller glia in the rat retina via TGF beta signaling. Development. 2005;132:3015-26 pubmed
Zamiri P, Masli S, Kitaichi N, Taylor A, Streilein J. Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci. 2005;46:908-19 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
532-R2
SKU :
532-R2-050
product name :
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF
Description :
The Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF from R&D Systems is derived from NS0. The Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF has been validated for the following applications: Bioactivity.
target :
TGF-beta RII
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
60-65 kDa, reducing conditions
theoretical molecular weight :
44.6 kDa (monomer)
gene symbol :
Tgfbr2
details of functionality :
Measured by its ability to inhibit TGF-beta 1 activity on HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 10-70 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62312.1
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse TGF-beta RII/(human) Fc Chimera
USD :
470 USD
alt names :
AAT3, EC 2.7.11, EC 2.7.11.30, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, tbetaR-II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbetaRII, TGFbeta-RII, TGFBR2, TGF-bRII, TGFR-2, transforming growth factor beta receptor type IIC, transforming growth factor, beta receptor II (70/80kDa), transforming growth factor, beta receptor II (70/80kDa) isoform 1, transforming growth factor, beta receptor II (70/80kDa) isoform 2, transforming growth factor, beta receptor II (70-80kD), Transforming growth factor-beta receptor type II
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.