product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse CCL17/TARC Protein
catalog :
529-TR-025
quantity :
25 ug
price :
269 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Pai C, Lin S, Liu C, Pan S, Hsu H, Chen Y, et al. Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis. Sci Rep. 2020;10:16772 pubmed publisher
Lee K, Zhang Z, Achuthan A, Fleetwood A, Smith J, Hamilton J, et al. IL-23 in arthritic and inflammatory pain development in mice. Arthritis Res Ther. 2020;22:123 pubmed publisher
Usuki S, Tamura N, Tamura T, Higashiyama S, Tanji K, Mitsutake S, et al. Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism. Biochem Biophys Rep. 2019;17:132-138 pubmed publisher
Cook A, Lee M, Saleh R, Khiew H, Christensen A, Achuthan A, et al. TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17. JCI Insight. 2018;3: pubmed publisher
Achuthan A, Cook A, Lee M, Saleh R, Khiew H, Chang M, et al. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest. 2016;126:3453-66 pubmed publisher
Geherin S, Gómez D, Glabman R, Ruthel G, Hamann A, Debes G. IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin. J Immunol. 2016;196:2514-2525 pubmed publisher
Loebbermann J, Durant L, Thornton H, Johansson C, Openshaw P. Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Proc Natl Acad Sci U S A. 2013;110:2987-92 pubmed publisher
Semmling V, Lukacs Kornek V, Thaiss C, Quast T, Hochheiser K, Panzer U, et al. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol. 2010;11:313-20 pubmed publisher
Kearley J, Buckland K, Mathie S, Lloyd C. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med. 2009;179:772-81 pubmed publisher
Kearley J, Robinson D, Lloyd C. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol. 2008;122:617-24.e6 pubmed publisher
Meyer E, Wurbel M, Staton T, Pichavant M, Kan M, Savage P, et al. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol. 2007;179:4661-71 pubmed
Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, et al. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli. Eur J Immunol. 2006;36:2116-27 pubmed
Bengtsson A, Ryan E, Giordano D, Magaletti D, Clark E. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood. 2004;104:1404-10 pubmed
product information
brand :
R&D Systems
master code :
529-TR
SKU :
529-TR-025
product name :
Recombinant Mouse CCL17/TARC Protein
description :
The Recombinant Mouse CCL17/TARC Protein from R&D Systems is derived from E. coli.
target :
CCL17/TARC
category :
Proteins and Enzymes
unit sizes :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
theoretical molecular weight :
7.9 kDa
gene symbol :
Ccl17
details of functionality :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR4. The ED50 for this effect is 2-8 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9WUZ6
source :
E. coli-derived Recombinant Mouse CCL17/TARC Protein
USD :
269 USD
alt names :
ABCD-2, CC chemokine TARC, C-C motif chemokine 17, chemokine (C-C motif) ligand 17, MGC138273, SCYA17, SCYA17MGC138271, small inducible cytokine subfamily A (Cys-Cys), member 17, Small-inducible cytokine A17, T cell-directed CC chemokine, TARC, TARCA-152E5.3, Thymus and activation-regulated chemokine
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.