Recombinant Mouse Notch-1 Fc Chimera Protein, CF | R&D Systems 5267-TK-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Notch-1 Fc Chimera Protein, CF

catalog :

5267-TK-050

quantity :

50 ug

price :

432 USD

citations: 3

Reference
Nandagopal N, Santat L, Lebon L, Sprinzak D, Bronner M, Elowitz M. Dynamic Ligand Discrimination in the Notch Signaling Pathway. Cell. 2018;172:869-880.e19 pubmed publisher
Lebon L, Lee T, Sprinzak D, Jafar Nejad H, Elowitz M. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. elife. 2014;3:e02950 pubmed publisher
Benner E, Luciano D, Jo R, Abdi K, Paez Gonzalez P, Sheng H, et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature. 2013;497:369-73 pubmed publisher

product information

master code :

5267-TK

SKU :

5267-TK-050

product name :

Recombinant Mouse Notch-1 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse Notch-1 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse Notch-1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Notch-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and EDTA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

110-120 kDa, reducing conditions

theoretical molecular weight :

80.7 kDa (monomer)

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse Notch-1 Fc Chimera at 2 ╡g/mL (100 ╡L/mL) can bind Recombinant Rat Jagged 1 Fc Chimera (Catalog # 599-JG) with an apparent KD 2 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAM28905

applications :

Binding Activity

source long :

Chinese Hamster Ovary cell line, CHO-derived mouse Notch-1 protein Mouse Notch-1 (Ala19 - Gln526) Accession # AAM28905 IEGRMDP Mouse IgG2A (Glu98 - Lys330) N-terminus C-terminus

source short :

CHO

USD :

432 USD

alt names :

EC 2.1.2.11, EC 3.4.21.68, hN1, Notch (Drosophila) homolog 1 (translocation-associated), notch 1Notch homolog 1, translocation-associated (Drosophila), Notch homolog 1, translocation-associated, Notch1, TAN1, TAN1neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.