Recombinant Human IL-34 Protein | R&D Systems 5265-IL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-34 Protein

catalog :

5265-IL

quantity :

10 ug

price :

329 USD

citations: 9

Reference
Lin K, Ma J, Peng Y, Sun M, Xu K, Wu R, et al. Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signaling. Sci Rep. 2019;9:16781 pubmed publisher
Sellgren C, Gracias J, Watmuff B, Biag J, Thanos J, Whittredge P, et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019;22:374-385 pubmed publisher
Vermi W, Micheletti A, Finotti G, Tecchio C, Calzetti F, Costa S, et al. slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP. Cancer Res. 2018;78:3544-3559 pubmed publisher
Ohgidani M, Kato T, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, et al. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells. Sci Rep. 2017;7:11882 pubmed publisher
Wang B, Ma Z, Wang M, Sun X, Tang Y, Li M, et al. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators Inflamm. 2017;2017:1567120 pubmed publisher
Cheng S, Tang H, Ren J, Chen X, Huang A, Chen J. Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo. PLoS ONE. 2017;12:e0179605 pubmed publisher
Foucher E, Blanchard S, Preisser L, Descamps P, Ifrah N, Delneste Y, et al. IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1Î±. Eur J Immunol. 2015;45:1092-102 pubmed publisher
Ohgidani M, Kato T, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, et al. Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease. Sci Rep. 2014;4:4957 pubmed publisher
Gow D, Garceau V, Pridans C, Gow A, Simpson K, Gunn Moore D, et al. Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine. 2013;61:630-8 pubmed publisher

product information

brand :

R&D Systems

master code :

5265-IL

SKU :

5265-IL-010

product name :

Recombinant Human IL-34 Protein

description :

The Recombinant Human IL-34 Protein from R&D Systems is derived from NS0. The Recombinant Human IL-34 Protein has been validated for the following applications: Bioactivity.

target :

IL-34

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

35-38 kDa, reducing conditions

theoretical molecular weight :

26.1 kDa

gene symbol :

IL34

details of functionality :

Measured in a cell proliferation assay using human peripheral blood monocytes. Lin, H. et al . (2008) Science 320 :807. The ED50 for this effect is 0.75-3.75 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

5265-IL

accessionNumbers :

NP_689669

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human IL-34 protein Asn21-Pro242, with a C-terminal 6-His tag

2020 USD :

329

2021 USD :

329 USD

alt names :

C16orf77, IL34, IL-34, interleukin 34

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.