product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-34 Protein
catalog :
5265-IL-010
quantity :
10 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 18
Reference
Finotti G, Pietronigro E, Balanzin C, Lonardi S, Constantin G, Chao M, et al. slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis. Cancer Immunol Res. 2023;11:1538-1552 pubmed publisher
Shirozu N, Ohgidani M, Hata N, Tanaka S, Inamine S, Sagata N, et al. Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease. Sci Rep. 2023;13:14842 pubmed publisher
Pan A, Audrain M, Sakakibara E, Joshi R, Zhu X, Wang Q, et al. Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice. bioRxiv. 2023;: pubmed publisher
Liaudanskaya V, Fiore N, Zhang Y, Milton Y, Kelly M, Coe M, et al. Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model. Cell Death Dis. 2023;14:496 pubmed publisher
Feige L, Kozaki T, Dias de Melo G, Guillemot V, Larrous F, Ginhoux F, et al. Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses. Viruses. 2022;15: pubmed publisher
Banerjee A, Lu Y, Do K, Mize T, Wu X, Chen X, et al. Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases. Front Cell Neurosci. 2021;15:629279 pubmed publisher
Poudel M, Kim G, Bhattarai P, Kim J, Choi H. Interleukin-34-CSF1R Signaling Axis Promotes Epithelial Cell Transformation and Breast Tumorigenesis. Int J Mol Sci. 2021;22: pubmed publisher
Piotrowska K, Słuczanowska Głąbowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, et al. Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis. Biomolecules. 2020;10: pubmed publisher
Ryan S, Gonzalez M, Garifallou J, Bennett F, WILLIAMS K, Sotuyo N, et al. Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection. Stem Cell Reports. 2020;14:703-716 pubmed publisher
Lin K, Ma J, Peng Y, Sun M, Xu K, Wu R, et al. Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signaling. Sci Rep. 2019;9:16781 pubmed publisher
Sellgren C, Gracias J, Watmuff B, Biag J, Thanos J, Whittredge P, et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019;22:374-385 pubmed publisher
Vermi W, Micheletti A, Finotti G, Tecchio C, Calzetti F, Costa S, et al. slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP. Cancer Res. 2018;78:3544-3559 pubmed publisher
Ohgidani M, Kato T, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, et al. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells. Sci Rep. 2017;7:11882 pubmed publisher
Wang B, Ma Z, Wang M, Sun X, Tang Y, Li M, et al. IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes. Mediators Inflamm. 2017;2017:1567120 pubmed publisher
Cheng S, Tang H, Ren J, Chen X, Huang A, Chen J. Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo. PLoS ONE. 2017;12:e0179605 pubmed publisher
Foucher E, Blanchard S, Preisser L, Descamps P, Ifrah N, Delneste Y, et al. IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1α. Eur J Immunol. 2015;45:1092-102 pubmed publisher
Ohgidani M, Kato T, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, et al. Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease. Sci Rep. 2014;4:4957 pubmed publisher
Gow D, Garceau V, Pridans C, Gow A, Simpson K, Gunn Moore D, et al. Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). Cytokine. 2013;61:630-8 pubmed publisher
image
image 1 :
R&D Systems 5265-IL-010 image 1
Graph showing dose-dependent bioactivity of Human IL-34 protein
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
5265-IL
SKU :
5265-IL-010
product name :
Recombinant Human IL-34 Protein
description :
The Recombinant Human IL-34 Protein from R&D Systems is derived from NS0. The Recombinant Human IL-34 Protein has been validated for the following applications: Bioactivity.
target :
IL-34
unit size :
10 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
35-38 kDa, reducing conditions
theoretical molecular weight :
26.1 kDa
gene symbol :
IL34
details of functionality :
Measured in a cell proliferation assay using human peripheral blood monocytes. Lin, H. et al . (2008) Science 320 :807. The ED50 for this effect is 0.75-3.75 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_689669
applications :
Bioactivity
product keywords :
5265-IL, rhIL-34, hIL-34,, 5265IL, cytokinegrowthfact, IL34, Interleukin 34, Interleukin-34, IL 34, cytokine, cytokines
source :
NS0-derived Recombinant Human IL-34 Protein
USD :
396
USD 2025 :
400 USD
alt names :
C16orf77, IL34, IL-34, interleukin 34
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.