Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF | R&D Systems 5260-MR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF

catalog :

5260-MR-050

quantity :

50 ug

price :

598 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Santer D, Minty G, Golec D, Lu J, May J, Namdar A, et al. Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells. PLoS Pathog. 2020;16:e1008515 pubmed publisher
Witte K, Gruetz G, Volk H, Looman A, Asadullah K, Sterry W, et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009;10:702-14 pubmed publisher

product information

master code :

5260-MR

SKU :

5260-MR-050

product name :

Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF

unit size :

50 ug

description :

The Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF from R&D Systems is derived from NS0. The Recombinant Human IL-28 R alpha/IFN-lambda R1 Fc Chimera, CF has been validated for the following applications: Binding Activity.

target :

IL-28 R alpha/IFN-lambda R1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

65-75 kDa, reducing conditions

theoretical molecular weight :

50.2 kDa (monomer)

gene symbol :

IFNLR1

details of functionality :

Measured by its binding ability in a functional ELISA. In a 100 ╡L reaction mixture containing rhIL-28 R alpha /Fc Chimera at 1 ╡g/mL and rhIL-28A (Catalog # 1587-IL) dilutions at 1-1000 ng/mL, the concentration of rhIL-28A that produces 50% of the optimal binding response is found to be approximately 40-200 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8IU57

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human IL-28 R alpha/IFN-lambda R1 protein Human IL-28 R alpha (Arg21 - Ala228) Accession # Q8IU57 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

598 USD

alt names :

class II cytokine receptor CRF2/12, CRF2/12, CRF2-12, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, IFN-lambda R1, IFN-lambda receptor 1, IFN-lambda-R1, IFNLR, IFNLR1, IL-28 receptor subunit alpha, IL28R alpha, IL-28R1, IL28RA, IL-28RA, IL-28R-alpha, Interferon lambda receptor 1, interferon lambda, receptor 1, interleukin 28 receptor A, interleukin 28 receptor, alpha, interleukin 28 receptor, alpha (interferon, lambda receptor), interleukin or cytokine receptor 2, interleukin-28 receptor subunit alpha, LICR2, Likely interleukin or cytokine receptor 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage