Recombinant Mouse Fas Ligand/TNFSF6 Protein, CF | R&D Systems 526-SA-050/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Fas Ligand/TNFSF6 Protein, CF

catalog :

526-SA-050/CF

quantity :

50 ug

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Lin Y, Belle I, Blasi M, Huang M, Buckley A, Rountree W, et al. Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity. Mol Ther Methods Clin Dev. 2020;17:532-544 pubmed publisher
Svandová E, Veselá B, Lesot H, Sadoine J, Poliard A, Matalova E. FasL Modulates Expression of Mmp2 in Osteoblasts. Front Physiol. 2018;9:1314 pubmed publisher
Wetzel M, Li L, Harms K, Roitbak T, Ventura P, Rosenberg G, et al. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death Differ. 2008;15:143-51 pubmed
Kovacic N, Lukic I, Grcevic D, Katavic V, Croucher P, Marusic A. The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J Immunol. 2007;178:3379-89 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

526-SA/CF

SKU :

526-SA-050/CF

product name :

Recombinant Mouse Fas Ligand/TNFSF6 Protein, CF

Description :

The Recombinant Mouse Fas Ligand/TNFSF6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Fas Ligand/TNFSF6 Protein, CF has been validated for the following applications: Bioactivity.

target :

Fas Ligand/TNFSF6

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

27-33 kDa, reducing conditions

theoretical molecular weight :

18 kDa

gene symbol :

Fasl

details of functionality :

Measured by its ability to induce apoptosis of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.25-1.5 µg/mL in the presence of 10 µg/mL of a cross-linking antibody Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ). This soluble Recombinant Mouse Fas Ligand/TNFSF6 has weak cytotoxic activity. It has no effects on A20 mouse B cell lymphoma cells which express mouse Fas. This is one of multiple forms available for this protein. Check R D Systems' website, www.RnDSystems.com, for a complete listing of the products.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q544E9

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Fas Ligand/TNFSF6 Protein

extended description :

A New rm FasL is Available! It has ~1000 fold better activity, lower endotoxin specification, and a HA tag!

USD :

470 USD

product details :

A New rm FasL is Available! It has ~1000 fold better activity, lower endotoxin specification, and a HA tag!

alt names :

apoptosis (APO-1) antigen ligand 1, Apoptosis antigen ligand, APT1LG1CD95L, APTL, CD178, CD178 antigen, CD95L, CD95-L, Fas antigen ligand, Fas ligand, Fas ligand (TNF superfamily, member 6), FASLCD95 ligand, FASLG, TNFSF6, TNFSF6FasL, tumor necrosis factor (ligand) superfamily, member 6, tumor necrosis factor ligand superfamily member 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage