This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-28B/IFN-lambda 3 Protein
catalog :
5259-IL
quantity :
25 ug
price :
339 USD
citations: 14
Reference
Santer D, Minty G, Golec D, Lu J, May J, Namdar A, et al. Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells. PLoS Pathog. 2020;16:e1008515 pubmed publisher
Chung J, Hong S, Seo N, Kim T, An H, Lee P, et al. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020;125:154833 pubmed publisher
Good C, Wells A, Coyne C. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5:eaau4255 pubmed publisher
Holly M, Smith J. Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells. J Virol. 2018;92: pubmed publisher
Sung P, Hong S, Chung J, Kim S, Park S, Kim H, et al. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017;7:3821 pubmed publisher
Jarret A, McFarland A, Horner S, Kell A, Schwerk J, Hong M, et al. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016;22:1475-1481 pubmed publisher
Kelly A, Robinson M, Roche G, Biron C, O Farrelly C, Ryan E. Immune Cell Profiling of IFN-? Response Shows pDCs Express Highest Level of IFN-?R1 and Are Directly Responsive via the JAK-STAT Pathway. J Interferon Cytokine Res. 2016;36:671-680 pubmed
Chang M, Liang K, Ku C, Lo C, Cheng Y, Hsu C, et al. Resistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms. Sci Rep. 2016;6:30799 pubmed publisher
Baños Lara M, Harvey L, Mendoza A, Simms D, Chouljenko V, Wakamatsu N, et al. Impact and regulation of lambda interferon response in human metapneumovirus infection. J Virol. 2015;89:730-42 pubmed publisher
Persson B, Jaffe A, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. PLoS ONE. 2014;9:e102368 pubmed publisher
Ding S, Khoury Hanold W, Iwasaki A, Robek M. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 2014;12:e1001758 pubmed publisher
Stone A, Giugliano S, Schnell G, Cheng L, Leahy K, Golden Mason L, et al. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013;9:e1003316 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Liu M, Zhou D, Wang X, Zhou W, Ye L, Li J, et al. IFN-?3 inhibits HIV infection of macrophages through the JAK-STAT pathway. PLoS ONE. 2012;7:e35902 pubmed publisher
product information
brand :
R&D Systems
master code :
5259-IL
SKU :
5259-IL-025
product name :
Recombinant Human IL-28B/IFN-lambda 3 Protein
description :
The Recombinant Human IL-28B/IFN-lambda 3 Protein from R&D Systems is derived from CHO. The Recombinant Human IL-28B/IFN-lambda 3 Protein has been validated for the following applications: Bioactivity.
target :
IL-28B/IFN-lambda 3
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS, NaCl and EDTA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
22 kDa, reducing conditions
theoretical molecular weight :
20.1 kDa
gene symbol :
IFNL3
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 1-5 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
5259-IL
accessionNumbers :
AAN28264
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived human IL-28B/IFN-lambda 3 protein Arg30-Val200, with the variant of Lys74Arg and a C-terminal 6-His tag
2020 USD :
339
2021 USD :
339 USD
alt names :
interleukin-28B, IFN-lambda 3, IL28B, IL-28B, IL28C, interferon, lambda 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.