product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-28B/IFN-lambda 3 Protein
catalog :
5259-IL-025
quantity :
25 ug
price :
394 USD
more info or order :
R&D Systems product webpage
citations: 24
Reference
Broadbent L, Bamford C, Lopez Campos G, Manzoor S, Courtney D, Ali A, et al. An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells. PLoS ONE. 2022;17:e0266412 pubmed publisher
De M, Bhushan A, Grubbe W, Roy S, Mendoza J, Chinnaswamy S. Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages. Genes Immun. 2022;23:73-84 pubmed publisher
Gan T, Zhou D, Huang Y, Xiao S, Ma Z, Hu X, et al. Development of a New Reverse Genetics System for Ebola Virus. mSphere. 2021;6: pubmed publisher
Kimura I, Konno Y, Uriu K, Hopfensperger K, Sauter D, Nakagawa S, et al. Sarbecovirus ORF6 proteins hamper induction of interferon signaling. Cell Rep. 2021;34:108916 pubmed publisher
Zhao X, Li C, Liu X, Chiu M, Wang D, Wei Y, et al. Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus. Stem Cell Reports. 2021;16:493-504 pubmed publisher
Lee H, Jung O, Hennighausen L. Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors. Res Sq. 2020;: pubmed publisher
De M, Bhushan A, Chinnaswamy S. Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes. J Leukoc Biol. 2020;: pubmed publisher
Onabajo O, Banday A, Stanifer M, Yan W, Obajemu A, Santer D, et al. Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor. Nat Genet. 2020;52:1283-1293 pubmed publisher
Syedbasha M, Bonfiglio F, Linnik J, Stuehler C, Wüthrich D, Egli A. Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway. Cell Rep. 2020;33:108211 pubmed publisher
Onabajo O, Banday A, Yan W, Obajemu A, Stanifer M, Santer D, et al. Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2. bioRxiv. 2020;: pubmed publisher
Santer D, Minty G, Golec D, Lu J, May J, Namdar A, et al. Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells. PLoS Pathog. 2020;16:e1008515 pubmed publisher
Chung J, Hong S, Seo N, Kim T, An H, Lee P, et al. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020;125:154833 pubmed publisher
Good C, Wells A, Coyne C. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5:eaau4255 pubmed publisher
Holly M, Smith J. Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells. J Virol. 2018;92: pubmed publisher
Sung P, Hong S, Chung J, Kim S, Park S, Kim H, et al. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017;7:3821 pubmed publisher
Jarret A, McFarland A, Horner S, Kell A, Schwerk J, Hong M, et al. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016;22:1475-1481 pubmed publisher
Kelly A, Robinson M, Roche G, Biron C, O Farrelly C, Ryan E. Immune Cell Profiling of IFN-? Response Shows pDCs Express Highest Level of IFN-?R1 and Are Directly Responsive via the JAK-STAT Pathway. J Interferon Cytokine Res. 2016;36:671-680 pubmed
Chang M, Liang K, Ku C, Lo C, Cheng Y, Hsu C, et al. Resistin reinforces interferon λ-3 to eliminate hepatitis C virus with fine-tuning from RETN single-nucleotide polymorphisms. Sci Rep. 2016;6:30799 pubmed publisher
Baños Lara M, Harvey L, Mendoza A, Simms D, Chouljenko V, Wakamatsu N, et al. Impact and regulation of lambda interferon response in human metapneumovirus infection. J Virol. 2015;89:730-42 pubmed publisher
Persson B, Jaffe A, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. PLoS ONE. 2014;9:e102368 pubmed publisher
Ding S, Khoury Hanold W, Iwasaki A, Robek M. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 2014;12:e1001758 pubmed publisher
Stone A, Giugliano S, Schnell G, Cheng L, Leahy K, Golden Mason L, et al. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013;9:e1003316 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Liu M, Zhou D, Wang X, Zhou W, Ye L, Li J, et al. IFN-?3 inhibits HIV infection of macrophages through the JAK-STAT pathway. PLoS ONE. 2012;7:e35902 pubmed publisher
product information
brand :
R&D Systems
master code :
5259-IL
SKU :
5259-IL-025
product name :
Recombinant Human IL-28B/IFN-lambda 3 Protein
description :
The Recombinant Human IL-28B/IFN-lambda 3 Protein from R&D Systems is derived from CHO. The Recombinant Human IL-28B/IFN-lambda 3 Protein has been validated for the following applications: Bioactivity.
target :
IL-28B/IFN-lambda 3
category :
Proteins and Enzymes
sizes available :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS, NaCl and EDTA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
22 kDa, reducing conditions
theoretical molecular weight :
20.1 kDa
gene symbol :
IFNL3
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 0.0800-0.800 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAN28264
applications :
Bioactivity
source :
CHO-derived Recombinant Human IL-28B/IFN-lambda 3 Protein
USD :
388
USD 2023 :
394 USD
alt names :
interleukin-28B, IFN-lambda 3, IL28B, IL-28B, IL28C, interferon, lambda 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.