Recombinant Human ST2/IL-33R Fc Chimera Protein, CF | R&D Systems 523-ST-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ST2/IL-33R Fc Chimera Protein, CF

catalog :

523-ST-100

quantity :

100 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Han K, Singh K, Rodman M, Hassanzadeh S, Baumer Y, Huffstutler R, et al. Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. Nutrients. 2021;13: pubmed publisher
Matilla L, Arrieta V, Jover E, García Peña A, Martínez Martínez E, Sadaba R, et al. Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1. Cells. 2020;9: pubmed publisher
Sun Z, Chang B, Huang A, Hao S, Gao M, Sun Y, et al. Plasma levels of soluble ST2, but not IL-33, correlate with the severity of alcoholic liver disease. J Cell Mol Med. 2019;23:887-897 pubmed publisher
Ramadan A, Daguindau E, Rech J, Chinnaswamy K, Zhang J, Hura G, et al. From proteomics to discovery of first-in-class ST2 inhibitors active in vivo. JCI Insight. 2018;3: pubmed publisher
Matsumoto K, Kouzaki H, Kikuoka H, Kato T, Tojima I, Shimizu S, et al. Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33. Allergol Int. 2018;67S:S32-S37 pubmed publisher
Akimoto M, Maruyama R, Takamaru H, Ochiya T, Takenaga K. Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment. Nat Commun. 2016;7:13589 pubmed publisher
Stojkovic S, Kaun C, Basílio J, Rauscher S, Hell L, Krychtiuk K, et al. Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation. Sci Rep. 2016;6:25171 pubmed publisher
Zhang Y, Zhang C, Zhuang R, Ma Y, Zhang Y, Yi J, et al. IL-33/ST2 correlates with severity of haemorrhagic fever with renal syndrome and regulates the inflammatory response in Hantaan virus-infected endothelial cells. PLoS Negl Trop Dis. 2015;9:e0003514 pubmed publisher
Seeber S, Ros F, Thorey I, Tiefenthaler G, Kaluza K, Lifke V, et al. A robust high throughput platform to generate functional recombinant monoclonal antibodies using rabbit B cells from peripheral blood. PLoS ONE. 2014;9:e86184 pubmed publisher
Gillibert Duplantier J, Duthey B, Sisirak V, Salaun D, Gargi T, Tredan O, et al. Gene expression profiling identifies sST2 as an effector of ErbB2-driven breast carcinoma cell motility, associated with metastasis. Oncogene. 2012;31:3516-24 pubmed publisher
Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. IL-33 mediates inflammatory responses in human lung tissue cells. J Immunol. 2010;185:5743-50 pubmed publisher
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan T, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005;23:479-90 pubmed

product information

master code :

523-ST

SKU :

523-ST-100

product name :

Recombinant Human ST2/IL-33R Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human ST2/IL-33R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ST2/IL-33R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ST2/IL-33R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

100 kDa, reducing conditions

theoretical molecular weight :

62.5 kDa (monomer)

gene symbol :

IL1RL1

details of functionality :

Measured by its ability to inhibit IL-33-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.03-0.12 ╡g/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

BAA02233

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human ST2/IL-33 R protein Human ST2 (Lys19-Phe328) Accession # BAA02233 IEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

456 USD

alt names :

DER4, DER4ST2growth stimulation-expressed, FIT-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL-33 R, IL33R, IL-33R, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, interleukin-1 receptor-like 1, Ly84, MGC32623, Protein ST2, ST2L, ST2V, T1, T1homolog of mouse growth stimulation-expressed

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage