This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat IL-10 Protein
catalog :
522-RLB-025
quantity :
25 ug
price :
466 USD
citations: 14
Reference
Kim S, Son Y. Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia. Int J Mol Sci. 2021;22: pubmed publisher
Lively S, Schlichter L. Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10). Front Cell Neurosci. 2018;12:215 pubmed publisher
Erkens T, Goeminne N, Kegels A, Byloos M, Vinken P. Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat. J Pharmacol Toxicol Methods. 2018;91:43-49 pubmed publisher
Lim J, Chung E, Son Y. A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ. Sci Rep. 2017;7:9417 pubmed publisher
Cambier L, de Couto G, Ibrahim A, Echavez A, Valle J, Liu W, et al. Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion. EMBO Mol Med. 2017;9:337-352 pubmed publisher
Stanisavljević S, Lukić J, Soković S, Mihajlovic S, Mostarica Stojkovic M, Miljkovic D, et al. Correlation of Gut Microbiota Composition with Resistance to Experimental Autoimmune Encephalomyelitis in Rats. Front Microbiol. 2016;7:2005 pubmed publisher
Ma H, Wang X, Wu M, Zhao X, Yuan X, Shi X. Interleukin-10 Contributes to Therapeutic Effect of Mesenchymal Stem Cells for Acute Liver Failure via Signal Transducer and Activator of Transcription 3 Signaling Pathway. Chin Med J (Engl). 2016;129:967-75 pubmed publisher
Siddiqui T, Lively S, Ferreira R, Wong R, Schlichter L. Expression and contributions of TRPM7 and KCa2.3/SK3 channels to the increased migration and invasion of microglia in anti-inflammatory activation states. PLoS ONE. 2014;9:e106087 pubmed publisher
Le Texier L, Durand J, Lavault A, Hulin P, Collin O, Le Bras Y, et al. LIMLE, a new molecule over-expressed following activation, is involved in the stimulatory properties of dendritic cells. PLoS ONE. 2014;9:e93894 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Ke Y, Jiang G, Sun D, Kaplan H, Shao H. Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis. Invest Ophthalmol Vis Sci. 2008;49:3999-4007 pubmed publisher
Oh J, Kim M, Shin M, Lee H, Ko J, Wee W, et al. The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells. 2008;26:1047-55 pubmed publisher
Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. Crit Care Med. 2005;33:2317-22 pubmed
Lynch A, Walsh C, Delaney A, Nolan Y, Campbell V, Lynch M. Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10--a role for IL-1 beta?. J Neurochem. 2004;88:635-46 pubmed
product information
master code :
522-RLB
SKU :
522-RLB-025
product name :
Recombinant Rat IL-10 Protein
unit size :
25 ug
description :
The Recombinant Rat IL-10 Protein from R&D Systems is derived from E. coli. The Recombinant Rat IL-10 Protein has been validated for the following applications: Bioactivity.
target :
IL-10
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Rat
observed molecular weight :
16 kDa, reducing conditions
theoretical molecular weight :
19 kDa (monomer)
details of functionality :
Measured in a cell proliferation assay using MC/9-2 mouse mast cells. Thompson-Snipes, L.á et al . (1991) J. Exp. Med. 173 :507. The ED50 for this effect is 0.12-0.72 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Rat IL-10 Protein Bioactivity
accessionNumbers :
P29456.1
applications :
Bioactivity
source long :
E. coli -derived rat IL-10 protein Ser19-Asn178
source short :
E. coli
USD :
466 USD
alt names :
CSIF, CSIFMGC126450, Cytokine synthesis inhibitory factor, GVHDS, IL10, IL10A, IL-10MGC126451, interleukin 10, interleukin-10, TGIF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.