product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat IL-18/IL-1F4 Protein
catalog :
521-RL-025
quantity :
25 ug
price :
274 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Bao J, Chen Z, Xu L, Wu L, Xiong Y. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. Aging (Albany NY). 2020;12:5152-5167 pubmed publisher
He Y, Moqbel S, Xu L, Ran J, Ma C, Xu K, et al. Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF‑κB and Wnt/β‑catenin signaling pathways. Mol Med Rep. 2019;20:312-322 pubmed publisher
Bao J, Ma C, Ran J, Xiong Y, Yan S, Wu L. Wnt/β-catenin and Hedgehog pathways are involved in the inflammatory effect of Interleukin 18 on rat chondrocytes. Oncotarget. 2017;8:109962-109972 pubmed publisher
Sudworth A, Vaage J, Inngjerdingen M, Kveberg L. Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset. J Leukoc Biol. 2017;102:1289-1298 pubmed publisher
Okuhara Y, Yokoe S, Iwasaku T, Eguchi A, Nishimura K, Li W, et al. Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity. Int J Cardiol. 2017;243:396-403 pubmed publisher
Boieri M, Ulvmoen A, Sudworth A, Lendrem C, Collin M, Dickinson A, et al. IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo. Oncoimmunology. 2017;6:e1274478 pubmed publisher
Tzekova N, Heinen A, Bunk S, Hermann C, Hartung H, Reipert B, et al. Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth. J Neuroinflammation. 2015;12:107 pubmed publisher
Guo W, Miyoshi K, Dubner R, Gu M, Li M, Liu J, et al. Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Mol Pain. 2014;10:35 pubmed publisher
Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci. 2008;28:12775-87 pubmed publisher
Haas C, Amin M, Allen B, Ruth J, Haines G, Woods J, et al. Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Arthritis Rheum. 2006;54:2402-14 pubmed
Jordan J, Guo R, Yun E, Sarma V, Warner R, Crouch L, et al. Role of IL-18 in acute lung inflammation. J Immunol. 2001;167:7060-8 pubmed
product information
brand :
R&D Systems
master code :
521-RL
SKU :
521-RL-025
product name :
Recombinant Rat IL-18/IL-1F4 Protein
description :
The Recombinant Rat IL-18/IL-1F4 Protein from R&D Systems is derived from E. coli. The Recombinant Rat IL-18/IL-1F4 Protein has been validated for the following applications: Bioactivity.
target :
IL-18/IL-1F4
category :
Proteins and Enzymes
sizes available :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris, NaCl, EDTA, TCEP and PEG 8000 with Trehalose and with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Rat
theoretical molecular weight :
18.4 kDa
gene symbol :
Il18
details of functionality :
Measured by its ability to induce mouse IFN-gamma secretion by activated mouse T cells. The ED50 for this effect is 10.0-60.0 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P97636.1
applications :
Bioactivity
source :
E. coli-derived Recombinant Rat IL-18/IL-1F4 Protein
USD :
269
USD 2023 :
274 USD
alt names :
Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.