Recombinant Rat IL-18/IL-1F4 Protein, CF | R&D Systems 521-RL-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat IL-18/IL-1F4 Protein, CF

catalog :

521-RL-025/CF

quantity :

25 ug

price :

300 USD

citations: 11

Reference
Bao J, Chen Z, Xu L, Wu L, Xiong Y. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. Aging (Albany NY). 2020;12:5152-5167 pubmed publisher
He Y, Moqbel S, Xu L, Ran J, Ma C, Xu K, et al. Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF‑κB and Wnt/β‑catenin signaling pathways. Mol Med Rep. 2019;20:312-322 pubmed publisher
Bao J, Ma C, Ran J, Xiong Y, Yan S, Wu L. Wnt/β-catenin and Hedgehog pathways are involved in the inflammatory effect of Interleukin 18 on rat chondrocytes. Oncotarget. 2017;8:109962-109972 pubmed publisher
Sudworth A, Vaage J, Inngjerdingen M, Kveberg L. Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset. J Leukoc Biol. 2017;102:1289-1298 pubmed publisher
Okuhara Y, Yokoe S, Iwasaku T, Eguchi A, Nishimura K, Li W, et al. Interleukin-18 gene deletion protects against sepsis-induced cardiac dysfunction by inhibiting PP2A activity. Int J Cardiol. 2017;243:396-403 pubmed publisher
Boieri M, Ulvmoen A, Sudworth A, Lendrem C, Collin M, Dickinson A, et al. IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo. Oncoimmunology. 2017;6:e1274478 pubmed publisher
Tzekova N, Heinen A, Bunk S, Hermann C, Hartung H, Reipert B, et al. Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth. J Neuroinflammation. 2015;12:107 pubmed publisher
Guo W, Miyoshi K, Dubner R, Gu M, Li M, Liu J, et al. Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Mol Pain. 2014;10:35 pubmed publisher
Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci. 2008;28:12775-87 pubmed publisher
Haas C, Amin M, Allen B, Ruth J, Haines G, Woods J, et al. Inhibition of angiogenesis by interleukin-4 gene therapy in rat adjuvant-induced arthritis. Arthritis Rheum. 2006;54:2402-14 pubmed
Jordan J, Guo R, Yun E, Sarma V, Warner R, Crouch L, et al. Role of IL-18 in acute lung inflammation. J Immunol. 2001;167:7060-8 pubmed

product information

master code :

521-RL/CF

SKU :

521-RL-025/CF

product name :

Recombinant Rat IL-18/IL-1F4 Protein, CF

unit size :

25 ug

description :

The Recombinant Rat IL-18/IL-1F4 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Rat IL-18/IL-1F4 Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-18/IL-1F4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris, EDTA, TCEP and PEG 8000 with Trehalose.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Rat

theoretical molecular weight :

18.4 kDa

gene symbol :

Il18

details of functionality :

Measured by its ability to induce mouse IFN-gamma secretion by activated mouse T cells. The ED50 for this effect is 10.0-60.0 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P97636.1

applications :

Bioactivity

source long :

E. coli -derived rat IL-18/IL-1F4 protein His37-Ser194, with an N-terminal Met

source short :

E. coli

USD :

300 USD

alt names :

Iboctadekin, IFN-gamma-inducing factor, IGIF, IGIFIL-1 gamma, IL18, IL-18MGC12320, IL-1F4, IL1F4iboctadekin, IL-1g, Interferon gamma-inducing factor, interleukin 18 (interferon-gamma-inducing factor), Interleukin-1 gamma, interleukin-18

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.