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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat PDGF-BB Protein, CF
catalog :
520-BB-050/CF
quantity :
50 ug
price :
341 USD
more info or order :
citations: 43
Reference
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Yao L, Rathnakar B, Kwon H, Sakashita H, Kim J, Rackley A, et al. Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing. Cell Rep. 2022;40:111192 pubmed publisher
Zhu P, Wang Z, Sun Z, Liao B, Cai Y. Recombinant platelet-derived growth factor-BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo. J Cell Mol Med. 2021;25:7472-7484 pubmed publisher
Kim S, Heo S, Brzostowski J, Kang D. Endosomal mTORC2 Is Required for Phosphoinositide-Dependent AKT Activation in Platelet-Derived Growth Factor-Stimulated Glioma Cells. Cancers (Basel). 2021;13: pubmed publisher
Reichert D, Adolph L, Köhler J, Buschmann T, Luedde T, Haussinger D, et al. Improved Recovery from Liver Fibrosis by Crenolanib. Cells. 2021;10: pubmed publisher
Liao Y, Wang Y, Wu C, Hsu F, Chien C, Lee Y. Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice. Int J Mol Sci. 2021;22: pubmed publisher
Díaz Lezama N, Wolf A, Koch S, Pfaller A, Biber J, Guillonneau X, et al. PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions. Int J Mol Sci. 2021;22: pubmed publisher
Kadrmas J, Beckerle M, Yoshigi M. Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha. Sci Rep. 2020;10:19303 pubmed publisher
Kip P, Tao M, Trocha K, MacArthur M, Peters H, Mitchell S, et al. Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease. J Am Heart Assoc. 2020;9:e016391 pubmed publisher
Carlström K, Zhu K, Ewing E, Krabbendam I, Harris R, Falcão A, et al. Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis. Nat Commun. 2020;11:4071 pubmed publisher
Lee C, Suk F, Twu Y, Liao Y. Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis. Int J Environ Res Public Health. 2020;17: pubmed publisher
Kim J, Lee K, Kim B, Lee S, Moon B, Baek S. Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cells. Korean J Physiol Pharmacol. 2020;24:241-248 pubmed publisher
Zanno A, Romer M, Fox L, Golden T, Jaeckle Santos L, Simmons R, et al. Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain. J Neurodev Disord. 2019;11:34 pubmed publisher
Mori K, Tsuchiya K, Nakamura S, Miyachi Y, Shiba K, Ogawa Y, et al. Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice. Cardiovasc Diabetol. 2019;18:83 pubmed publisher
Marshall A, Luo W, Wang X, Lin T, Cai Y, Guzman R. Medial artery calcification increases neointimal hyperplasia after balloon injury. Sci Rep. 2019;9:8193 pubmed publisher
López Bellido R, Puig S, Huang P, Tsai C, Turner H, Galko M, et al. Growth factor signaling regulates mechanical nociception in flies and vertebrates. J Neurosci. 2019;: pubmed publisher
Qiu L, Xu C, Jiang H, Li W, Tong S, Xia H. Cantharidin Attenuates the Proliferation and Migration of Vascular Smooth Muscle Cells through Suppressing Inflammatory Response. Biol Pharm Bull. 2019;42:34-42 pubmed publisher
Iso Y, Usui S, Toyoda M, Spees J, Umezawa A, Suzuki H. Bone marrow-derived mesenchymal stem cells inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia after arterial injury in rats. Biochem Biophys Rep. 2018;16:79-87 pubmed publisher
Lo H, Ma M, Shieh J, Chen H, Wu W. Naked physically synthesized gold nanoparticles affect migration, mitochondrial activity, and proliferation of vascular smooth muscle cells. Int J Nanomedicine. 2018;13:3163-3176 pubmed publisher
Hudson C, Kimura T, Duggirala A, Sala Newby G, Newby A, Bond M. Dual Role of CREB in The Regulation of VSMC Proliferation: Mode of Activation Determines Pro- or Anti-Mitogenic Function. Sci Rep. 2018;8:4904 pubmed publisher
Kang C, Han Y, Kim J, Oh J, Cho Y, Lee E. 4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes. Sci Rep. 2017;7:14192 pubmed publisher
Jia S, Rodriguez M, Williams A, Yuan J. Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation. Sci Rep. 2017;7:5075 pubmed publisher
Peng L, Huang X, Jin X, Jing Z, Yang L, Zhou Y, et al. Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling. Exp Gerontol. 2017;96:73-81 pubmed publisher
Su T, Shiau C, Jao P, Yang N, Tai W, Liu C, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017;7:1728 pubmed publisher
Shen Y, Wu Y, Zheng Y, Ao F, Kang K, Wan Y, et al. Responses of adventitial CD34+ vascular wall-resident stem/progenitor cells and medial smooth muscle cells to carotid injury in rats. Exp Mol Pathol. 2016;101:332-340 pubmed publisher
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Nakamura T, Ito T, Uchida M, Hijioka M, Igarashi H, Oono T, et al. PSCs and GLP-1R: occurrence in normal pancreas, acute/chronic pancreatitis and effect of their activation by a GLP-1R agonist. Lab Invest. 2014;94:63-78 pubmed publisher
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Lo H, Tsai Y, Du W, Tsou C, Wu W. A naturally occurring carotenoid, lutein, reduces PDGF and H?O? signaling and compromised migration in cultured vascular smooth muscle cells. J Biomed Sci. 2012;19:18 pubmed publisher
Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, et al. Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol. 2010;176:1950-8 pubmed publisher
O Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, et al. Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J Bone Miner Res. 2007;22:1679-89 pubmed
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Oda T, Ohka S, Nomoto A. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Biochem Biophys Res Commun. 2004;319:1253-64 pubmed
image
image 1 :
R&D Systems 520-BB-050/CF image 1
Graph showing dose-dependent bioactivity of rat PDGF-BB protein
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
520-BB/CF
SKU :
520-BB-050/CF
product name :
Recombinant Rat PDGF-BB Protein, CF
Description :
The Recombinant Rat PDGF-BB Protein, CF from R&D Systems is derived from E. coli. The Recombinant Rat PDGF-BB Protein, CF has been validated for the following applications: Bioactivity.
target :
PDGF-BB
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Rat
theoretical molecular weight :
25 kDa
gene symbol :
Pdgfb
details of functionality :
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 1.5-6 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q05028.1
applications :
Bioactivity
source :
E. coli-derived Recombinant Rat PDGF-BB Protein
USD :
341 USD
alt names :
c-sis;IBGC5;PDGF2;PDGF-2;PDGFB;Platelet-derived growth factor subunit B;SIS;SSV, PDGFBB
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.