Recombinant Human Siglec-1 Protein, CF | R&D Systems 5197-SL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Siglec-1 Protein, CF

catalog :

5197-SL-050

quantity :

50 ug

price :

525 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Affandi A, Grabowska J, Olesek K, Lopez Venegas M, Barbaria A, Rodriguez E, et al. Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes. Proc Natl Acad Sci U S A. 2020;117:27528-27539 pubmed publisher
Perez Zsolt D, Erkizia I, Pino M, Garcia Gallo M, Martin M, Benet S, et al. Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry. Nat Microbiol. 2019;: pubmed publisher
Xu F, Bandara A, Akiyama H, Eshaghi B, Stelter D, Keyes T, et al. Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways. Proc Natl Acad Sci U S A. 2018;115:E9041-E9050 pubmed publisher
Oliveira J, Karrar S, Rainbow D, Pinder C, Clarke P, Rubio García A, et al. The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus. Arthritis Res Ther. 2018;20:152 pubmed publisher
Eggink L, Roby K, Cote R, Kenneth Hoober J. An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. J Immunother Cancer. 2018;6:28 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Xiong Y, Yu J, Li C, Zhu L, Wu L, Zhong R. The role of Siglec-1 and SR-BI interaction in the phagocytosis of oxidized low density lipoprotein by macrophages. PLoS ONE. 2013;8:e58831 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

5197-SL

SKU :

5197-SL-050

product name :

Recombinant Human Siglec-1 Protein, CF

Description :

The Recombinant Human Siglec-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-1 Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-1/CD169

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>80%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

175 kDa-190 kDa, reducing conditions

theoretical molecular weight :

173.9 kDa

gene symbol :

SIGLEC1

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 0.6-3 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9BZZ2

applications :

Bioactivity

source :

NS0-derived Recombinant Human Siglec-1 Protein

USD :

525 USD

alt names :

CD169, FLJ00051, sialic acid binding Ig-like lectin 1, sialoadhesin, sialoadhesin, Siglec1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage