Recombinant Human IL-17A/F Heterodimer Protein | R&D Systems 5194-IL-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-17A/F Heterodimer Protein

catalog :

5194-IL-025

quantity :

25 ug

price :

425 USD

citations: 5

Reference
Crawford M, Borcherding N, Karandikar N. IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes. PLoS ONE. 2023;18:e0285166 pubmed publisher
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 2015;212:619-31 pubmed publisher
Adams K, Abraham V, Spielman D, Kolls J, Rubenstein R, Conner G, et al. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. PLoS ONE. 2014;9:e103263 pubmed publisher
Chang Y, Al Alwan L, Risse P, Roussel L, Rousseau S, Halayko A, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol. 2011;127:1046-53.e1-2 pubmed publisher
Kisand K, Bøe Wolff A, Podkrajsek K, Tserel L, Link M, Kisand K, et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med. 2010;207:299-308 pubmed publisher

product information

master code :

5194-IL

SKU :

5194-IL-025

product name :

Recombinant Human IL-17A/F Heterodimer Protein

unit size :

25 ug

description :

The Recombinant Human IL-17A/F Heterodimer Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-17A/F Heterodimer Protein has been validated for the following applications: Bioactivity.

target :

IL-17A/F Heterodimer

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

theoretical molecular weight :

IL-17A: 15.7 kDa and IL-17F: 15 kDa

details of functionality :

Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al . (1995) Immunity 3 :811. The ED50 for this effect is 3-15 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q16552 (IL-17A) Q96PD4 (IL-17F)

applications :

Bioactivity

source long :

E. coli -derived human IL-17A/F Heterodimer protein Met Human IL-17A (Ile20-Ala155) Accession # Q16552 Met Human IL-17F (Arg31-Gln163) Accession # Q96PD4 N-terminus C-terminus

source short :

E. coli

USD :

425 USD

alt names :

CTLA8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, Cytotoxic T-Lymphocyte-Associated Protein 8, IL17, IL-17, IL-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A, interleukin-17A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.