Recombinant Human Gremlin Protein, CF | R&D Systems 5190-GR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Gremlin Protein, CF

catalog :

5190-GR-050

quantity :

50 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 17

Reference
Shihan M, Novo S, Wang Y, Sheppard D, Atakilit A, Arnold T, et al. αVβ8 integrin targeting to prevent posterior capsular opacification. JCI Insight. 2021;6: pubmed publisher
Sung N, Kim N, Surh Y, Park S. Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling Pathway. Int J Mol Sci. 2020;21: pubmed publisher
Park S, Sung N, Choi B, Kim W, Kim S, Surh Y. Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer. Br J Cancer. 2020;: pubmed publisher
Sung N, Kim N, Bae N, Jo H, Park S. DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells. Biosci Rep. 2020;40: pubmed publisher
Schivo S, Khurana S, Govindaraj K, Scholma J, Kerkhofs J, Zhong L, et al. ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cell Signal. 2020;68:109471 pubmed publisher
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
Dutton L, O Neill C, Medina R, Brazil D. No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells. J Biol Chem. 2019;294:18041-18045 pubmed publisher
Ren J, Smid M, Iaria J, Salvatori D, van Dam H, Zhu H, et al. Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. Breast Cancer Res. 2019;21:109 pubmed publisher
Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvonen M, de la Roche M. Organoid culture media formulated with growth factors of defined cellular activity. Sci Rep. 2019;9:6193 pubmed publisher
Li Q, Huo Y, Guo Y, Zheng X, Sun W, Hao Z. Generation and Applications of a DNA Aptamer against Gremlin-1. Molecules. 2017;22: pubmed publisher
Li A, Figueroa S, Jiang T, Wu P, Widelitz R, Nie Q, et al. Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme. Nat Commun. 2017;8:ncomms14139 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
O Reilly S, Ciechomska M, Cant R, van Laar J. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-? (TGF-?) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J Biol Chem. 2014;289:9952-60 pubmed publisher
Alborzinia H, Schmidt Glenewinkel H, Ilkavets I, Breitkopf Heinlein K, Cheng X, Hortschansky P, et al. Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists. J Cell Sci. 2013;126:117-27 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Kim M, Yoon S, Lee S, Ha S, Kim H, Kim J, et al. Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE. 2012;7:e35100 pubmed publisher
Mitola S, Ravelli C, Moroni E, Salvi V, Leali D, Ballmer Hofer K, et al. Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood. 2010;116:3677-80 pubmed publisher

image

image 1 :

Recombinant Human Gremlin Protein Bioactivity

product information

brand :

R&D Systems

master code :

5190-GR

SKU :

5190-GR-050

product name :

Recombinant Human Gremlin Protein, CF

description :

The Recombinant Human Gremlin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Gremlin Protein, CF has been validated for the following applications: Bioactivity.

target :

Gremlin

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

25-30 kDa, under reducing conditions

theoretical molecular weight :

19.7 kDa

gene symbol :

GREM1

details of functionality :

Measured by its ability to inhibit alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.025-0.15 µg/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O60565

applications :

Bioactivity

source :

NS0-derived Recombinant Human Gremlin Protein, CF

USD :

377

USD 2023 :

377 USD

alt names :

Cell proliferation-inducing gene 2 protein, CKTSF1B1gremlin 1, cysteine knot superfamily, homolog, Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis), DAN domain family member 2, DAND2, DAND2GREMLIN, Down-regulated in Mos-transformed cells protein, DRM, DRMMGC126660, GREM1, gremlin, gremlin 1, gremlin 1-like protein, gremlin-1, IHG-2, Increased in high glucose protein 2, increased in high glucose-2, proliferation-inducing gene 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage