This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Kallikrein 6 Protein, CF
catalog :
5164-SE
quantity :
10 ug
price :
339 USD
citations: 5
Reference
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, et al. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med. 2018;10: pubmed publisher
Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Bostrom F, et al. Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS ONE. 2013;8:e53250 pubmed publisher
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD. Mol Ther. 2013;21:31-41 pubmed publisher
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder J, et al. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011;32:1187-92 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher
product information
brand :
R&D Systems
master code :
5164-SE
SKU :
5164-SE-010
product name :
Recombinant Human Kallikrein 6 Protein, CF
description :
The Recombinant Human Kallikrein 6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 6 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Kallikrein 6/Neurosin
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in Sodium Citrate.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
35 kDa, reducing conditions
theoretical molecular weight :
26 kDa
gene symbol :
KLK6
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC (Catalog # ES014 ). The specific activity is 1300 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
5164-SE
accessionNumbers :
Q92876
applications :
Enzyme Activity
source :
Mouse myeloma cell line, NS0-derived human Kallikrein 6/Neurosin protein Glu17-Lys244, with a C-terminal 10-His tag
2020 USD :
339
2021 USD :
339 USD
alt names :
Bssp, EC 3.4.21, EC 3.4.21.-, hK6, kallikrein 6 (neurosin, zyme), kallikrein-6, kallikrein-related peptidase 6, KLK6, Klk7, neurosin, Protease M, protease, serine, 18, PRSS18, PRSS9, PRSS9MGC9355, Serine protease 18, Serine protease 9, SP59, Zyme
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.