Recombinant Human Kallikrein 6 Protein, CF | R&D Systems 5164-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Kallikrein 6 Protein, CF

catalog :

5164-SE-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Bosc E, Anastasie J, Soualmia F, Coric P, Kim J, Wang L, et al. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022;13:959 pubmed publisher
Bouzid H, Soualmia F, Oikonomopoulou K, Soosaipillai A, Walker F, Louati K, et al. Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis. Biomolecules. 2022;12: pubmed publisher
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, et al. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med. 2018;10: pubmed publisher
Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Bostrom F, et al. Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS ONE. 2013;8:e53250 pubmed publisher
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD. Mol Ther. 2013;21:31-41 pubmed publisher
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder J, et al. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011;32:1187-92 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

5164-SE

SKU :

5164-SE-010

product name :

Recombinant Human Kallikrein 6 Protein, CF

Description :

The Recombinant Human Kallikrein 6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 6 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Kallikrein 6/Neurosin

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Sodium Citrate.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

35 kDa, reducing conditions

theoretical molecular weight :

26 kDa

gene symbol :

KLK6

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC (Catalog # ES014 ). The specific activity is 1300 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q92876

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human Kallikrein 6 Protein

USD :

423 USD

alt names :

Bssp, EC 3.4.21, EC 3.4.21.-, hK6, kallikrein 6 (neurosin, zyme), kallikrein-6, kallikrein-related peptidase 6, KLK6, Klk7, neurosin, Protease M, protease, serine, 18, PRSS18, PRSS9, PRSS9MGC9355, Serine protease 18, Serine protease 9, SP59, Zyme

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage