Recombinant Human MMP-13 Protein, CF | R&D Systems 511-MM product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MMP-13 Protein, CF

catalog :

511-MM

quantity :

10 ug

price :

379 USD

citations: 8

Reference
Knapinska A, Hart M, Drotleff G, Fields G. Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11. Molecules. 2019;24: pubmed publisher
Lee C, Wang C, Chen M, Chuang K, Cheng T, Jian T, et al. Development of an inflammatory tissue-selective chimeric TNF receptor. Cytokine. 2019;113:340-346 pubmed publisher
Ye Y, Toczek J, Gona K, Kim H, Han J, Razavian M, et al. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Sci Rep. 2018;8:11647 pubmed publisher
He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, et al. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE. 2015;10:e0122700 pubmed publisher
Ozeki N, Kawai R, Yamaguchi H, Hiyama T, Kinoshita K, Hase N, et al. IL-1?-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells. Exp Cell Res. 2014;323:165-77 pubmed publisher
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G. Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2013;54:1014-25 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, et al. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J Cell Physiol. 2007;210:417-27 pubmed

product information

brand :

R&D Systems

master code :

511-MM

SKU :

511-MM-010

product name :

Recombinant Human MMP-13 Protein, CF

description :

The Recombinant Human MMP-13 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-13 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

MMP-13

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES, NaCl, CaCl2 and Brij-35.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

58 kDa, reducing conditions

theoretical molecular weight :

52 kDa

gene symbol :

MMP13

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 2,000 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

511-MM

accessionNumbers :

P45452

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human MMP-13 protein Leu20-Cys471

2020 USD :

379

2021 USD :

379 USD

alt names :

CLG 3, CLG3EC 3.4.24, collagenase 3, EC 3.4.24.-, EC 3.4.24.22, EC 3.4.24.24, EC 3.4.24.35, EC 3.4.24.65, EC 3.4.24.7, MANDP1, matrix metallopeptidase 13 (collagenase 3), matrix metalloproteinase 13 (collagenase 3), Matrix metalloproteinase-13, MMP13, MMP-13

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.