product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human MMP-13 Protein, CF
catalog :
511-MM-010
quantity :
10 ug
price :
470 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Lan X, Zhang W, Zhu J, Huang H, Mo K, Guo H, et al. dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing. Invest Ophthalmol Vis Sci. 2022;63:14 pubmed publisher
Mancarella S, Serino G, Dituri F, Cigliano A, Ribback S, Wang J, et al. Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis. Cell Death Differ. 2020;27:2330-2343 pubmed publisher
Knapinska A, Hart M, Drotleff G, Fields G. Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11. Molecules. 2019;24: pubmed publisher
Lee C, Wang C, Chen M, Chuang K, Cheng T, Jian T, et al. Development of an inflammatory tissue-selective chimeric TNF receptor. Cytokine. 2019;113:340-346 pubmed publisher
Ye Y, Toczek J, Gona K, Kim H, Han J, Razavian M, et al. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Sci Rep. 2018;8:11647 pubmed publisher
He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, et al. The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. PLoS ONE. 2015;10:e0122700 pubmed publisher
Ozeki N, Kawai R, Yamaguchi H, Hiyama T, Kinoshita K, Hase N, et al. IL-1?-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells. Exp Cell Res. 2014;323:165-77 pubmed publisher
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G. Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2013;54:1014-25 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, et al. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J Cell Physiol. 2007;210:417-27 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
511-MM
SKU :
511-MM-010
product name :
Recombinant Human MMP-13 Protein, CF
Description :
The Recombinant Human MMP-13 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-13 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
MMP-13
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in MES, NaCl, CaCl2 and Brij-35.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
58 kDa, reducing conditions
theoretical molecular weight :
52 kDa
gene symbol :
MMP13
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 2,000 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P45452
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human MMP-13 Protein
USD :
470 USD
alt names :
CLG 3, CLG3EC 3.4.24, collagenase 3, EC 3.4.24.-, EC 3.4.24.22, EC 3.4.24.24, EC 3.4.24.35, EC 3.4.24.65, EC 3.4.24.7, MANDP1, matrix metallopeptidase 13 (collagenase 3), matrix metalloproteinase 13 (collagenase 3), Matrix metalloproteinase-13, MMP13, MMP-13
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.