product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-15 Protein
catalog :
5096-BM-005
quantity :
5 ug
price :
487 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, et al. Generation of functional oocytes from male mice in vitro. Nature. 2023;615:900-906 pubmed publisher
Ito H, Emori C, Kobayashi M, Maruyama N, Fujii W, Naito K, et al. Cooperative effects of oocytes and estrogen on the forkhead box L2 expression in mural granulosa cells in mice. Sci Rep. 2022;12:20158 pubmed publisher
Soejima Y, Iwata N, Nakayama N, Hirata S, Nakano Y, Yamamoto K, et al. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells. Int J Mol Sci. 2022;23: pubmed publisher
Haas C, Oliveira F, Rovani M, Ferst J, Vargas S, Vieira A, et al. Bone morphogenetic protein 15 intrafollicular injection inhibits ovulation in cattle. Theriogenology. 2022;182:148-154 pubmed publisher
Iizuka T, Wakae K, Ono M, Suzuki T, Mizumoto Y, Kitamura K, et al. Activation-induced cytidine deaminase is a possible regulator of cross-talk between oocytes and granulosa cells through GDF-9 and SCF feedback system. Sci Rep. 2021;11:3833 pubmed publisher
De los Reyes M, Palomino J, Araujo A, Flores J, Ramirez G, Parraguez V, et al. Cyclooxygenase 2 messenger RNA levels in canine follicular cells: interrelationship with GDF-9, BMP-15, and progesterone. Domest Anim Endocrinol. 2021;74:106529 pubmed publisher
Yadav H, Lal B. Cellular localization and seasonal variation in BMP15 expression in ovary of the catfish Clarias batrachus and its role in ovarian steroidogenesis. Theriogenology. 2019;129:14-22 pubmed publisher
Liu C, Yuan B, Chen H, Xu M, Sun X, Xu J, et al. Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways. Cell Physiol Biochem. 2018;46:213-225 pubmed publisher
Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, et al. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun. 2017;8:15680 pubmed publisher
Jiajie T, Yanzhou Y, Hoi Hung A, Zi Jiang C, Wai Yee C. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Sci Rep. 2017;7:41304 pubmed publisher
Kong N, Xu X, Zhang Y, Wang Y, Hao X, Zhao Y, et al. Natriuretic peptide type C induces sperm attraction for fertilization in mouse. Sci Rep. 2017;7:39711 pubmed publisher
Mottershead D, Sugimura S, Al Musawi S, Li J, Richani D, White M, et al. Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality. J Biol Chem. 2015;290:24007-20 pubmed publisher
Sudiman J, Sutton McDowall M, Ritter L, White M, Mottershead D, Thompson J, et al. Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PLoS ONE. 2014;9:e103563 pubmed publisher
Chang H, Cheng J, Klausen C, Leung P. BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells. Mol Endocrinol. 2013;27:2093-104 pubmed publisher
Demars J, Fabre S, Sarry J, Rossetti R, Gilbert H, Persani L, et al. Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep. PLoS Genet. 2013;9:e1003482 pubmed publisher
Mottershead D, Ritter L, Gilchrist R. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod. 2012;18:121-8 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Celestino J, Lima Verde I, Bruno J, Matos M, Chaves R, Saraiva M, et al. Steady-state level of bone morphogenetic protein-15 in goat ovaries and its influence on in vitro development and survival of preantral follicles. Mol Cell Endocrinol. 2011;338:1-9 pubmed publisher
Sugiura K, Su Y, Li Q, Wigglesworth K, Matzuk M, Eppig J. Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod. 2009;81:833-41 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
5096-BM
SKU :
5096-BM-005
product name :
Recombinant Human BMP-15 Protein
Description :
The Recombinant Human BMP-15 Protein from R&D Systems is derived from CHO. The Recombinant Human BMP-15 Protein has been validated for the following applications: Bioactivity.
target :
BMP-15/GDF-9B
category :
Proteins and Enzymes
unit size :
5 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in HCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
15 kDa, reducing conditions
theoretical molecular weight :
13.9 kDa
gene symbol :
BMP15
details of functionality :
Measured by its ability to induce Smad3 phosphorylation in P19 mouse embryonal carcinoma cells. Approximately 10 ng/mL can effectively induce Smad3 phosphorylation.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O95972
applications :
Bioactivity
source :
CHO-derived Recombinant Human BMP-15 Protein
USD :
487 USD
alt names :
BMP15, BMP-15, bone morphogenetic protein 15, GDF-9B, Growth/differentiation factor 9B, ODG2, POF4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.