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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-6 Protein
catalog :
507-BP-020
quantity :
20 ug
price :
582 USD
more info or order :
citations: 74
Reference
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Charlebois E, Pantopoulos K. Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes. PLoS ONE. 2021;16:e0253475 pubmed publisher
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Krouwels A, Iljas J, Kragten A, Dhert W, Oner F, Tryfonidou M, et al. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. Int J Mol Sci. 2020;21: pubmed publisher
An P, Wang J, Wang H, Jiang L, Wang J, Min J, et al. Gnpat does not play an essential role in systemic iron homeostasis in murine model. J Cell Mol Med. 2020;24:4118-4126 pubmed publisher
Yin H, Kalra L, Lai Z, Guimaro M, Aber L, Warner B, et al. Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice. Sci Rep. 2020;10:2967 pubmed publisher
Seo D, Jung S, Park J, Lee J, Ha J, Kim M, et al. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway. EBioMedicine. 2019;49:55-71 pubmed publisher
Gooding S, Olechnowicz S, Morris E, Armitage A, Arezes J, Frost J, et al. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Nat Commun. 2019;10:4533 pubmed publisher
Ren J, Smid M, Iaria J, Salvatori D, van Dam H, Zhu H, et al. Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. Breast Cancer Res. 2019;21:109 pubmed publisher
Malinverno M, Maderna C, Abu Taha A, Corada M, Orsenigo F, Valentino M, et al. Endothelial cell clonal expansion in the development of cerebral cavernous malformations. Nat Commun. 2019;10:2761 pubmed publisher
Moghieb A, Tesfay L, Nie S, Gritsenko M, Fillmore T, Jacobs J, et al. A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification. Sci Rep. 2019;9:7264 pubmed publisher
Nürnberger S, Lindner C, Maier J, Strohmeier K, Wurzer C, Slezak P, et al. Adipose-tissue-derived therapeutic cells in their natural environment as an autologous cell therapy strategy: the microtissue-stromal vascular fraction. Eur Cell Mater. 2019;37:113-133 pubmed publisher
Lee J, Kwon S, Kim J, Jang H, Lee N, Hwang J, et al. Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease. Sci Rep. 2019;9:564 pubmed publisher
Ogata Y, Mabuchi Y, Shinoda K, Horiike Y, Mizuno M, Otabe K, et al. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Regen Ther. 2018;8:20-28 pubmed publisher
Peeters T, Monteagudo S, Tylzanowski P, Luyten F, Lories R, Cailotto F. SMOC2 inhibits calcification of osteoprogenitor and endothelial cells. PLoS ONE. 2018;13:e0198104 pubmed publisher
Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Mitrofan C, Appleby S, Nash G, Mallat Z, Chilvers E, Upton P, et al. Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J Biol Chem. 2017;292:13714-13726 pubmed publisher
Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher
Breitkopf Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, et al. BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut. 2017;66:939-954 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Choi Y, Park Y, Ha C, Kim J, Heo J, Han W, et al. Different characteristics of mesenchymal stem cells isolated from different layers of full term placenta. PLoS ONE. 2017;12:e0172642 pubmed publisher
Torti S, Lemler E, Mueller B, Popp A, Torti F. Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts. Clin Exp Pharmacol. 2016;6: pubmed publisher
Yu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed publisher
Kim B, Kim H, Kim S, Haegeman G, Tsang B, Dhanasekaran D, et al. Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway. Cancer Res Treat. 2017;49:338-349 pubmed publisher
Moutos F, Glass K, Compton S, Ross A, Gersbach C, Guilak F, et al. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proc Natl Acad Sci U S A. 2016;113:E4513-22 pubmed publisher
Lai Z, Yin H, Cabrera Perez J, Guimaro M, Afione S, Michael D, et al. Aquaporin gene therapy corrects Sjögren's syndrome phenotype in mice. Proc Natl Acad Sci U S A. 2016;113:5694-9 pubmed publisher
Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, et al. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015;75:2254-63 pubmed publisher
Nio Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, et al. Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology. 2015;156:1494-503 pubmed publisher
Zumbrennen Bullough K, Wu Q, Core A, Canali S, Chen W, Theurl I, et al. MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription. J Biol Chem. 2014;289:23796-808 pubmed publisher
Ye K, Felimban R, Traianedes K, Moulton S, Wallace G, Chung J, et al. Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold. PLoS ONE. 2014;9:e99410 pubmed publisher
Liu G, Liu Y, Lian W, Zhao Z, Yi T, Zhou H. Reduced BMP6 expression by DNA methylation contributes to EMT and drug resistance in breast cancer cells. Oncol Rep. 2014;32:581-8 pubmed publisher
Jakobsen R, Østrup E, Zhang X, Mikkelsen T, Brinchmann J. Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE. 2014;9:e96615 pubmed publisher
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Lee G, Kang D, Ha Y, Jung Y, Chung J, Min K, et al. Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer. 2014;110:1634-44 pubmed publisher
Mleczko Sanecka K, Roche F, da Silva A, Call D, D Alessio F, Ragab A, et al. Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood. 2014;123:1574-85 pubmed publisher
Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, et al. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev. 2014;23:541-54 pubmed publisher
Long J, Badal S, Wang Y, Chang B, Rodriguez A, Danesh F. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem. 2013;288:36202-14 pubmed publisher
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, et al. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A. 2013;110:E1426-35 pubmed publisher
Huse K, Bakkebø M, Walchli S, Oksvold M, Hilden V, Forfang L, et al. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE. 2012;7:e46117 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Erceg S, Lukovic D, Moreno Manzano V, Stojkovic M, Bhattacharya S. Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012;Chapter 1:Unit 1H.5 pubmed publisher
Mottershead D, Ritter L, Gilchrist R. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod. 2012;18:121-8 pubmed publisher
Huse K, Bakkebø M, Oksvold M, Forfang L, Hilden V, Stokke T, et al. Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur J Immunol. 2011;41:3135-45 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Meynard D, Vaja V, Sun C, Corradini E, Chen S, Lopez Otin C, et al. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011;118:747-56 pubmed publisher
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed publisher
Grcevic D, Kusec R, Kovacic N, Lukić A, Lukic I, Ivcevic S, et al. Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leuk Res. 2010;34:742-51 pubmed publisher
Campbell B, Kendall N, Baird D. Effect of direct ovarian infusion of bone morphogenetic protein 6 (BMP6) on ovarian function in sheep. Biol Reprod. 2009;81:1016-23 pubmed publisher
Sugiura K, Su Y, Li Q, Wigglesworth K, Matzuk M, Eppig J. Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod. 2009;81:833-41 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil A, et al. Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J Cell Biol. 2007;179:1569-82 pubmed
Zilberberg L, Ten Dijke P, Sakai L, Rifkin D. A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol. 2007;8:41 pubmed
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
Kersten C, Dosen G, Myklebust J, Sivertsen E, Hystad M, Smeland E, et al. BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3. Exp Hematol. 2006;34:72-81 pubmed
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, et al. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene. 2004;331:17-31 pubmed
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, et al. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol. 2003;23:5664-79 pubmed
image
image 1 :
R&D Systems 507-BP-020 image 1
Recombinant Human BMP-6 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
507-BP
SKU :
507-BP-020
product name :
Recombinant Human BMP-6 Protein
description :
The Recombinant Human BMP-6 Protein from R&D Systems is derived from NS0. The Recombinant Human BMP-6 Protein has been validated for the following applications: Bioactivity.
target :
BMP-6
unit size :
20 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
18 kDa, reducing conditions
theoretical molecular weight :
15 kDa (monomer)
gene symbol :
BMP6
details of functionality :
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.02-0.15 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P22004
applications :
Bioactivity
product keywords :
507-BP, rhBMP-6, hBMP-6, 5O7-BP,, 507BP, cytokinegrowthfact, BMP6, BMP 6, Bone, cytokine, cytokines
source :
NS0-derived Recombinant Human BMP-6 Protein
USD :
567
USD 2025 :
582 USD
alt names :
BMP6, BMP-6, bone morphogenetic protein 6, vegetal related growth factor (TGFB-related), vegetal-related (TGFB related) cytokine, VG-1-R, VG-1-related protein, Vg1-related sequence, VGR, Vgr-1, VGR1
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.