product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat IL-6 Protein
catalog :
506-RL-010
quantity :
10 ug
price :
237 USD
more info or order :
R&D Systems product webpage
citations: 22
Reference
Alhouayek M, Stafberg L, Karlsson J, Bergström S, Fowler C. Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study. Sci Rep. 2020;10:6314 pubmed publisher
Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, et al. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. Theranostics. 2019;9:3980-3991 pubmed publisher
Li Q, Cao Q, Wang C, Nguyen H, Wang X, Zheng G, et al. Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. J Leukoc Biol. 2019;105:809-819 pubmed publisher
Dubovy P, Klusáková I, Hradilová Svíženská I, Brazda V, Kohoutková M, Joukal M. A Conditioning Sciatic Nerve Lesion Triggers a Pro-regenerative State in Primary Sensory Neurons Also of Dorsal Root Ganglia Non-associated With the Damaged Nerve. Front Cell Neurosci. 2019;13:11 pubmed publisher
Erkens T, Goeminne N, Kegels A, Byloos M, Vinken P. Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat. J Pharmacol Toxicol Methods. 2018;91:43-49 pubmed publisher
Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, et al. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med. 2015;7:211-26 pubmed publisher
Tsukahara T, Watanabe K, Watanabe T, Yamagami H, Sogawa M, Tanigawa T, et al. Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol. 2015;185:185-96 pubmed publisher
Weinkopff T, Mackenzie C, Eversole R, Lammie P. Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators. PLoS Negl Trop Dis. 2014;8:e2893 pubmed publisher
Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014;4:4260 pubmed publisher
Gupta S, Hirota M, Waugh S, Murakami I, Suzuki T, Muraguchi M, et al. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem. 2014;289:8706-19 pubmed publisher
Zhang J, Li Y, Shan K, Wang L, Qiu W, Lu Y, et al. Sublytic C5b-9 induces IL-6 and TGF-?1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBP? acetylation. FASEB J. 2014;28:1511-25 pubmed publisher
Lim S, Park E, You B, Jung Y, Park A, Park S, et al. Neuronal synapse formation induced by microglia and interleukin 10. PLoS ONE. 2013;8:e81218 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Oh J, McCloskey M, Blong C, Bendickson L, Nilsen Hamilton M, Sakaguchi D. Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus. J Neurosci Res. 2010;88:2798-809 pubmed publisher
Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, et al. Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal. 2009;21:151-60 pubmed publisher
Whitaker K, Reyes T. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology. 2008;54:509-20 pubmed
Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci. 2007;25:649-58 pubmed
Roche M, Diamond M, Kelly J, Finn D. In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids. J Neuroimmunol. 2006;181:57-67 pubmed
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
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product information
brand :
R&D Systems
master code :
506-RL
SKU :
506-RL-010
product name :
Recombinant Rat IL-6 Protein
unit size :
10 ug
description :
The Recombinant Rat IL-6 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Rat IL-6 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-6
category :
Proteins and Enzymes
alt names :
B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A
buffer :
Supplied as a 0.2 µm filtered solution in Sodium Acetate with BSA as a carrier protein.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Rat
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening. 3 months, -20 to -70 °C under sterile conditions after opening.
theoretical molecular weight :
22 kDa
gene symbol :
Il6
details of functionality :
Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al . (1987) J. Immunol. 139 :813. The ED50 for this effect is 0.01-0.06 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P20607.1
applications :
Bioactivity
source :
E. coli-derived Recombinant Rat IL-6 Protein
USD :
219
Jul-22 :
237 USD
sizes available :
10 ug (also 50 ug)
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.