Recombinant Rat IL-6 Protein | R&D Systems 506-RL-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat IL-6 Protein

catalog :

506-RL-010

quantity :

10 ug (also 50 ug)

price :

256 USD

citations: 28

Reference
Lauraine M, de Taffin de Tilques M, Melamed Kadosh D, Cherqaoui B, Rincheval V, Prevost E, et al. TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis. Arthritis Res Ther. 2024;26:131 pubmed publisher
Lazarevi x107 M, Stegnjai x107 G, Jevti x107 B, Despotovi x107 S, Ignjatovi x107 x, Stanisavljevi x107 S, et al. Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity. J Neuroinflammation. 2024;21:26 pubmed publisher
Jang S, Kim J, Kim C, Kim I. Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats. J Cardiovasc Dev Dis. 2023;10: pubmed publisher
Zhao Y, Deng J, Liu H, Wei J, Fan H, Liu M, et al. Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats. J Neuroinflammation. 2022;19:144 pubmed publisher
Ding X, Yang W, Ren Q, Hu J, Yang S, Han W, et al. Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma. J Neuroinflammation. 2020;17:190 pubmed publisher
Alhouayek M, Stafberg L, Karlsson J, Bergström S, Fowler C. Effects of orthotopic implantation of rat prostate tumour cells upon components of the N-acylethanolamine and monoacylglycerol signalling systems: an mRNA study. Sci Rep. 2020;10:6314 pubmed publisher
Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, et al. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. Theranostics. 2019;9:3980-3991 pubmed publisher
Li Q, Cao Q, Wang C, Nguyen H, Wang X, Zheng G, et al. Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. J Leukoc Biol. 2019;105:809-819 pubmed publisher
Dubovy P, Klusáková I, Hradilová Svíženská I, Brazda V, Kohoutková M, Joukal M. A Conditioning Sciatic Nerve Lesion Triggers a Pro-regenerative State in Primary Sensory Neurons Also of Dorsal Root Ganglia Non-associated With the Damaged Nerve. Front Cell Neurosci. 2019;13:11 pubmed publisher
Erkens T, Goeminne N, Kegels A, Byloos M, Vinken P. Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat. J Pharmacol Toxicol Methods. 2018;91:43-49 pubmed publisher
Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, et al. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med. 2015;7:211-26 pubmed publisher
Tsukahara T, Watanabe K, Watanabe T, Yamagami H, Sogawa M, Tanigawa T, et al. Tumor necrosis factor Î± decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol. 2015;185:185-96 pubmed publisher
Weinkopff T, Mackenzie C, Eversole R, Lammie P. Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators. PLoS Negl Trop Dis. 2014;8:e2893 pubmed publisher
Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014;4:4260 pubmed publisher
Gupta S, Hirota M, Waugh S, Murakami I, Suzuki T, Muraguchi M, et al. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem. 2014;289:8706-19 pubmed publisher
Zhang J, Li Y, Shan K, Wang L, Qiu W, Lu Y, et al. Sublytic C5b-9 induces IL-6 and TGF-?1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBP? acetylation. FASEB J. 2014;28:1511-25 pubmed publisher
Lim S, Park E, You B, Jung Y, Park A, Park S, et al. Neuronal synapse formation induced by microglia and interleukin 10. PLoS ONE. 2013;8:e81218 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Oh J, McCloskey M, Blong C, Bendickson L, Nilsen Hamilton M, Sakaguchi D. Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus. J Neurosci Res. 2010;88:2798-809 pubmed publisher
Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, et al. Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell Signal. 2009;21:151-60 pubmed publisher
Oh J, Kim M, Shin M, Lee H, Ko J, Wee W, et al. The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells. 2008;26:1047-55 pubmed publisher
Whitaker K, Reyes T. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration. Neuropharmacology. 2008;54:509-20 pubmed
Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci. 2007;25:649-58 pubmed
Roche M, Diamond M, Kelly J, Finn D. In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids. J Neuroimmunol. 2006;181:57-67 pubmed
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
Cao Z, Gao Y, Bryson J, Hou J, Chaudhry N, Siddiq M, et al. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci. 2006;26:5565-73 pubmed
Fernandes A, Falcão A, Silva R, Gordo A, Gama M, Brito M, et al. Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin. J Neurochem. 2006;96:1667-79 pubmed
Berasain C, García Trevijano E, Castillo J, Erroba E, Lee D, Prieto J, et al. Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology. 2005;128:424-32 pubmed

product information

master code :

506-RL

SKU :

506-RL-010

product name :

Recombinant Rat IL-6 Protein

unit size :

10 ug (also 50 ug)

description :

The Recombinant Rat IL-6 Protein from R&D Systems is derived from E. coli. The Recombinant Rat IL-6 Protein has been validated for the following applications: Bioactivity.

target :

IL-6

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Sodium Acetate with BSA as a carrier protein.

conjugate :

Unconjugated

species :

Rat

theoretical molecular weight :

22 kDa

gene symbol :

Il6

details of functionality :

Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. etáal . (1987) J. Immunol. 139 :813. The ED50 for this effect is 17.5-140 pg/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P20607.1

applications :

Bioactivity

source long :

E. coli -derived rat IL-6 protein Phe25-Thr211, with an N-terminal Met

source short :

E. coli

USD :

256 USD

alt names :

B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening. 3 months, -20 to -70 ░C under sterile conditions after opening.