Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein, CF | R&D Systems 505-PR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein, CF

catalog :

505-PR-100

quantity :

100 ug

price :

529 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Huang B, Yuan Y, Li T, Ding S, Zhang W, Gu Y, et al. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface. Sci Rep. 2016;6:24323 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Ambrosio A, Taelman V, Lee H, Metzinger C, Coffinier C, De Robertis E. Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Dev Cell. 2008;15:248-60 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Serpe M, Umulis D, Ralston A, Chen J, Olson D, Avanesov A, et al. The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev Cell. 2008;14:940-53 pubmed publisher
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

505-PR

SKU :

505-PR-100

product name :

Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein, CF

Description :

The Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

BMPR-IB/ALK-6

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

40 kDa (monomer)

gene symbol :

BMPR1B

details of functionality :

Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.5-1.5 µg/mL in the presence of 30 ng/mL of rhBMP-4.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O00238

applications :

Bioactivity

source :

NS0-derived Recombinant Human BMPR-IB/ALK-6 Fc Chimera Protein

USD :

529 USD

alt names :

activin receptor-like kinase 6, ALK-6, ALK6CDw293, BMP type-1B receptor, BMPR1B, BMPR-1B, BMPRIB, bone morphogenetic protein receptor type-1B, bone morphogenetic protein receptor, type IB, CDw293, CDw293 antigen, EC 2.7.11, EC 2.7.11.30, serine/threonine receptor kinase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage