Recombinant Mouse DLL1 Fc Chimera Protein, CF | R&D Systems 5026-DL-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse DLL1 Fc Chimera Protein, CF

catalog :

5026-DL-050

quantity :

50 ug

price :

432 USD

citations: 13

Reference
Nauman M, Varshney S, Choi J, Augenlicht L, Stanley P. EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1. Sci Rep. 2023;13:17473 pubmed publisher
Kim I, Ghosh A, Bundschuh N, Hinte L, Petrosyan E, von Meyenn F, et al. Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells. Sci Adv. 2022;8:eabj4928 pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Silkenstedt E, Arenas F, Colom Sanmartí B, Xargay Torrent S, Higashi M, Giró A, et al. Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy. J Exp Clin Cancer Res. 2019;38:446 pubmed publisher
Kaylan K, Berg I, Biehl M, Brougham Cook A, Jain I, Jamil S, et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. elife. 2018;7: pubmed publisher
Liu L, Charville G, Cheung T, Yoo B, Santos P, Schroeder M, et al. Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Cell Stem Cell. 2018;23:544-556.e4 pubmed publisher
Takeuchi H, Schneider M, Williamson D, Ito A, Takeuchi M, Handford P, et al. Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. Proc Natl Acad Sci U S A. 2018;115:E8395-E8402 pubmed publisher
Varshney S, Stanley P. Notch Ligand Binding Assay Using Flow Cytometry. Bio Protoc. 2017;7: pubmed publisher
Kostrzewski T, Borg A, Meng Y, Filipovic I, Male V, Wack A, et al. Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development. J Immunol. 2018;200:1370-1381 pubmed publisher
Zhang Y, Zhu G, Xiao H, Liu X, Han G, Chen G, et al. CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells. J Cell Mol Med. 2017;21:3658-3669 pubmed publisher
Antfolk D, Sjöqvist M, Cheng F, Isoniemi K, Duran C, Rivero Muller A, et al. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. Proc Natl Acad Sci U S A. 2017;114:E4574-E4581 pubmed publisher
Lebon L, Lee T, Sprinzak D, Jafar Nejad H, Elowitz M. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. elife. 2014;3:e02950 pubmed publisher
Driver E, Sillers L, Coate T, Rose M, Kelley M. The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Dev Biol. 2013;376:86-98 pubmed publisher

product information

master code :

5026-DL

SKU :

5026-DL-050

product name :

Recombinant Mouse DLL1 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse DLL1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse DLL1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

DLL1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HEPES and EDTA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

94 kDa, reducing conditions

theoretical molecular weight :

81.4 kDa (monomer)

gene symbol :

Dll1

details of functionality :

Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.25-1 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q61483

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse DLL1 protein Mouse DLL1 (Ser22-Gln516) Accession # Q61483 LIEGRMDP Mouse IgG2A (Glu98-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

Delta, delta (Drosophila)-like 1, Delta 1, Delta1, delta-like 1 (Drosophila), delta-like protein 1, DL1, Drosophila Delta homolog 1, H-Delta-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.