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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat IL-1 beta/IL-1F2 Protein
catalog :
501-RL-010
quantity :
10 ug (also 50 ug)
price :
349 USD
more info or order :
citations: 65
Reference
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Ho D, Chang P, Lin W, Huang Y, Lin J, Huang K, et al. Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis. Int J Mol Sci. 2020;21: pubmed publisher
de Almeida M, Souza C, Dourado N, da Silva A, Ferreira R, David J, et al. Phytoestrogen Agathisflavone Ameliorates Neuroinflammation-Induced by LPS and IL-1β and Protects Neurons in Cocultures of Glia/Neurons. Biomolecules. 2020;10: pubmed publisher
Moqbel S, He Y, Xu L, Ma C, Ran J, Xu K, et al. Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside. Oxid Med Cell Longev. 2020;2020:7540197 pubmed publisher
Liu Z, Wang X, Li L, Wei G, Zhao M. Hydrogen Sulfide Protects against Paraquat-Induced Acute Liver Injury in Rats by Regulating Oxidative Stress, Mitochondrial Function, and Inflammation. Oxid Med Cell Longev. 2020;2020:6325378 pubmed publisher
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H. Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. Aging (Albany NY). 2019;11:12532-12545 pubmed publisher
Ma C, Wu L, Song L, He Y, Adel Abdo Moqbel S, Yan S, et al. The pro-inflammatory effect of NR4A3 in osteoarthritis. J Cell Mol Med. 2019;: pubmed publisher
Carstensen Kirberg M, Röhrig K, Niersmann C, Ouwens D, Belgardt B, Roden M, et al. Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E. PLoS ONE. 2019;14:e0213650 pubmed publisher
Mai C, Wei X, Gui W, Xu Y, Zhang J, Lin Z, et al. Differential regulation of GSK-3β in spinal dorsal horn and in hippocampus mediated by interleukin-1beta contributes to pain hypersensitivity and memory deficits following peripheral nerve injury. Mol Pain. 2019;15:1744806919826789 pubmed publisher
Lian W, Ko J, Wu R, Sun Y, Chen Y, Wu S, et al. MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12. Cell Death Dis. 2018;9:919 pubmed publisher
Guendisch U, Weiss J, Ecoeur F, Riker J, Kaupmann K, Kallen J, et al. Pharmacological inhibition of ROR?t suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS ONE. 2017;12:e0188391 pubmed publisher
Clark A, Kanekura K, Lavagnino Z, Spears L, Abreu D, Mahadevan J, et al. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Sci Rep. 2017;7:5611 pubmed publisher
Stojadinovic O, Wikramanayake T, Villasante Fricke A, Yin N, Liang L, Hinde E, et al. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1?-mediated signaling. Heliyon. 2017;3:e00309 pubmed publisher
Natoli R, Fernando N, Madigan M, Chu Tan J, Valter K, Provis J, et al. Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration. Mol Neurodegener. 2017;12:31 pubmed publisher
Guntermann C, Piaia A, Hamel M, Theil D, Rubic Schneider T, del Rio Espinola A, et al. Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations. JCI Insight. 2017;2:e91127 pubmed publisher
Wu P, Kuo L, Su F, Chen S, Hsu T, Li C, et al. High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy. Sci Rep. 2017;7:40840 pubmed publisher
Terashima Y, Kakutani K, Yurube T, Takada T, Maeno K, Hirata H, et al. Expression of adiponectin receptors in human and rat intervertebral disc cells and changes in receptor expression during disc degeneration using a rat tail temporary static compression model. J Orthop Surg Res. 2016;11:147 pubmed
Kangwantas K, Pinteaux E, Penny J. The extracellular matrix protein laminin-10 promotes blood-brain barrier repair after hypoxia and inflammation in vitro. J Neuroinflammation. 2016;13:25 pubmed publisher
Delpech J, Saucisse N, Parkes S, Lacabanne C, Aubert A, Casenave F, et al. Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci. 2015;35:3022-33 pubmed publisher
Arous C, Ferreira P, Dermitzakis E, Halban P. Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression. J Biol Chem. 2015;290:6653-69 pubmed publisher
Tsukahara T, Watanabe K, Watanabe T, Yamagami H, Sogawa M, Tanigawa T, et al. Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol. 2015;185:185-96 pubmed publisher
Lazzaro M, Bettegazzi B, Barbariga M, Codazzi F, Zacchetti D, Alessio M. Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J Neuroinflammation. 2014;11:164 pubmed publisher
Chentouf M, Guzman C, Hamze M, Gross R, Lajoix A, Peraldi Roux S. Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells. PLoS ONE. 2014;9:e102889 pubmed publisher
Dahllöf M, Christensen D, Harving M, Wagner B, Mandrup Poulsen T, Lundh M. HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interferon Cytokine Res. 2015;35:63-70 pubmed publisher
Vistnes M, Aronsen J, Lunde I, Sjaastad I, Carlson C, Christensen G. Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. PLoS ONE. 2014;9:e89621 pubmed publisher
Lim S, Park E, You B, Jung Y, Park A, Park S, et al. Neuronal synapse formation induced by microglia and interleukin 10. PLoS ONE. 2013;8:e81218 pubmed publisher
Macco R, Pelizzoni I, Consonni A, Vitali I, Giacalone G, Martinelli Boneschi F, et al. Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation. J Neuroinflammation. 2013;10:130 pubmed publisher
Lee C, Lee B, Arnold S, Isoherranen N, Morgan E. Nitric oxide and interleukin-1? stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes. J Pharmacol Exp Ther. 2014;348:141-52 pubmed publisher
Steelman A, Smith R, Welsh C, Li J. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem. 2013;288:23776-87 pubmed publisher
Weaver J, Taylor Fishwick D. Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway. Mol Cell Endocrinol. 2013;369:35-41 pubmed publisher
Hull R, Srivastava P, D Souza Z, Atanur S, Mechta Grigoriou F, Game L, et al. Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1? synthesis in macrophages. BMC Genomics. 2013;14:92 pubmed publisher
Owyang A, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, et al. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases. MAbs. 2011;3:49-60 pubmed
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Schwarznau A, Hanson M, Sperger J, Schram B, Danobeitia J, Greenwood K, et al. IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J Cell Physiol. 2009;220:341-7 pubmed publisher
Gonzalez P, Schiöth H, Lasaga M, Scimonelli T. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav Immun. 2009;23:817-22 pubmed publisher
Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci. 2008;28:12775-87 pubmed publisher
Husberg C, Nygard S, Finsen A, Damas J, Frigessi A, Oie E, et al. Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. J Mol Cell Cardiol. 2008;45:261-9 pubmed publisher
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Russo T, Beanan J, Olson R, Macdonald U, Luke N, Gill S, et al. Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect Immun. 2008;76:3577-86 pubmed publisher
Paintlia A, Paintlia M, Singh A, Singh I. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008;73:1381-93 pubmed publisher
Koo J, Duman R. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A. 2008;105:751-6 pubmed publisher
Engström L, Rosén K, Angel A, Fyrberg A, Mackerlova L, Konsman J, et al. Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology. 2008;149:1436-50 pubmed publisher
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Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
Fernandes A, Falcão A, Silva R, Gordo A, Gama M, Brito M, et al. Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin. J Neurochem. 2006;96:1667-79 pubmed
Frewert S, Stockhammer F, Warschewske G, Zenclussen A, Rupprecht S, Volk H, et al. Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neurosci Lett. 2004;364:145-8 pubmed
Nedrebø T, Reed R, Jonsson R, Berg A, Wiig H. Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats. J Physiol. 2004;556:193-202 pubmed
Sergejeva S, Hoshino H, Yoshihara S, Kashimoto K, Lotvall J, Linden A. A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo. Regul Pept. 2004;117:149-54 pubmed
Blais V, Zhang J, Rivest S. In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology. 2002;143:4820-7 pubmed
product information
master code :
501-RL
SKU :
501-RL-010
product name :
Recombinant Rat IL-1 beta/IL-1F2 Protein
unit size :
10 ug (also 50 ug)
description :
The Recombinant Rat IL-1 beta/IL-1F2 Protein from R&D Systems is derived from E. coli. The Recombinant Rat IL-1 beta/IL-1F2 Protein has been validated for the following applications: Bioactivity.
target :
IL-1 beta/IL-1F2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MES, NaCl, EDTA, DTT and PEG 8000 with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Rat
theoretical molecular weight :
17 kDa
gene symbol :
Il1b
details of functionality :
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 0.300-1.50 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Rat IL-1 beta/IL-1F2 Protein Bioactivity
accessionNumbers :
Q63264
applications :
Bioactivity
source long :
E. coli -derived rat IL-1 beta/IL-1F2 protein Val117-Ser268, with an N-terminal Met
source short :
E. coli
USD :
349 USD
alt names :
catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.