product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Leptin Protein, CF
catalog :
498-OB-01M
quantity :
1 mg
price :
248 USD
more info or order :
citations: 76
Reference
van Krieken P, Odermatt T, Borsigova M, Bluher M, Wueest S, Konrad D. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling. Mol Metab. 2021;54:101341 pubmed publisher
Aasmul Olsen K, Henriksen N, Nguyen D, Heckmann A, Thymann T, Sangild P, et al. Milk Osteopontin for Gut, Immunity and Brain Development in Preterm Pigs. Nutrients. 2021;13: pubmed publisher
Hoffmann A, Ebert T, Hankir M, Flehmig G, Kloting N, Jessnitzer B, et al. Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice. Nutrients. 2021;13: pubmed publisher
Geisler C, Ghimire S, Bruggink S, Miller K, Weninger S, Kronenfeld J, et al. A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity. Cell Rep. 2021;35:109301 pubmed publisher
Díaz Catalán D, Alcarraz Vizán G, Castaño C, de Pablo S, Rodríguez Comas J, Fernandez Perez A, et al. BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet. Mol Metab. 2021;53:101251 pubmed publisher
Shetty A, Suresh P. A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1/ mmu-miR-204-5p/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice. J Steroid Biochem Mol Biol. 2021;209:105843 pubmed publisher
Li C, Meng F, Lei Y, Liu J, Zhang J, Liu F, et al. Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade. Mol Psychiatry. 2020;: pubmed publisher
Cheng Y, Liu J. Effect of Lactobacillus rhamnosus GG on Energy Metabolism, Leptin Resistance, and Gut Microbiota in Mice with Diet-Induced Obesity. Nutrients. 2020;12: pubmed publisher
Hosaka S, Yamada T, Takahashi K, Dan T, Kaneko K, Kodama S, et al. Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance. Front Pharmacol. 2020;11:943 pubmed publisher
Zhang W, Jin Y, Wang D, Cui J. Neuroprotective effects of leptin on cerebral ischemia through JAK2/STAT3/PGC-1-mediated mitochondrial function modulation. Brain Res Bull. 2020;156:118-130 pubmed publisher
Frodermann V, Rohde D, Courties G, Severe N, Schloss M, Amatullah H, et al. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med. 2019;25:1761-1771 pubmed publisher
Torres D, Pitts M, Hashimoto A, Berry M. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019;11: pubmed publisher
Chen M, Wilson E, Cui Z, Sun H, Shrestha Y, Podyma B, et al. Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling. Mol Metab. 2019;25:142-153 pubmed publisher
Wang Z, Aguilar E, Luna J, Dunai C, Khuat L, Le C, et al. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019;25:141-151 pubmed publisher
Li M, Vera N, Yang Y, Zhang B, Ni W, Ziso Qejvanaj E, et al. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat Commun. 2018;9:5103 pubmed publisher
Lee C, Kim H, Lee Y, Kang G, Lim H, Lee S, et al. Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation. Cell Rep. 2018;25:934-946.e5 pubmed publisher
Smith M, Katsouri L, Virtue S, Choudhury A, Vidal Puig A, Ashford M, et al. Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018;25:278-287.e4 pubmed publisher
Philbrick K, Branscum A, Wong C, Turner R, Iwaniec U. Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice. Sci Rep. 2018;8:14790 pubmed publisher
Lee Y, Hsu H, Kao P, Shiao Y, Yeh S, Shie F, et al. Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation. Int J Mol Sci. 2018;19: pubmed publisher
Zeng Q, Luo X, Han M, Liu W, Li H. Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity. EBioMedicine. 2018;32:43-49 pubmed publisher
Millership S, Da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S, et al. Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018;128:3369-3381 pubmed publisher
Kleinert M, Kotzbeck P, Altendorfer Kroath T, Birngruber T, Tschop M, Clemmensen C. Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice. Mol Metab. 2018;13:77-82 pubmed publisher
Rawle D, Li D, Swedberg J, Wang L, Soares D, Harrich D. HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain. MBio. 2018;9: pubmed publisher
Kim G, Shi G, Somlo D, Haataja L, Song S, Long Q, et al. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J Clin Invest. 2018;128:1125-1140 pubmed publisher
Xie G, Swiderska Syn M, Jewell M, Machado M, Michelotti G, Premont R, et al. Loss of pericyte smoothened activity in mice with genetic deficiency of leptin. BMC Cell Biol. 2017;18:20 pubmed publisher
Yuan D, Yi X, Zhao Y, Poon C, Bullock K, Hansen K, et al. Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity. J Control Release. 2017;263:172-184 pubmed publisher
Mosialou I, Shikhel S, Liu J, Maurizi A, Luo N, He Z, et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. 2017;543:385-390 pubmed publisher
Raciti G, Spinelli R, Desiderio A, Longo M, Parrillo L, Nigro C, et al. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity. Sci Rep. 2017;7:43526 pubmed publisher
Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, et al. ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure. Diabetes. 2017;66:1146-1158 pubmed publisher
Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, et al. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. Nat Med. 2017;23:79-90 pubmed publisher
Morais R, Hilzendeger A, Visniauskas B, Todiras M, Alenina N, Mori M, et al. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism. Am J Physiol Heart Circ Physiol. 2017;312:H437-H445 pubmed publisher
Gerriets V, Danzaki K, Kishton R, Eisner W, Nichols A, Saucillo D, et al. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. Eur J Immunol. 2016;46:1970-83 pubmed publisher
Wang M, Luo L, Yao L, Wang C, Jiang K, Liu X, et al. Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus. Sci Rep. 2016;6:25399 pubmed publisher
Kim M, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nat Immunol. 2015;16:525-33 pubmed publisher
Tadokoro S, Ide S, Tokuyama R, Umeki H, Tatehara S, Kataoka S, et al. Leptin promotes wound healing in the skin. PLoS ONE. 2015;10:e0121242 pubmed publisher
Mejia P, Treviño Villarreal J, Hine C, Harputlugil E, Lang S, Calay E, et al. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat Commun. 2015;6:6050 pubmed publisher
Tillman E, Morgan D, Rahmouni K, Swoap S. Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice. PLoS ONE. 2014;9:e107206 pubmed publisher
Falcone J, Salameh T, Yi X, Cordy B, Mortell W, Kabanov A, et al. Intranasal administration as a route for drug delivery to the brain: evidence for a unique pathway for albumin. J Pharmacol Exp Ther. 2014;351:54-60 pubmed publisher
Yoshino S, Satoh T, Yamada M, Hashimoto K, Tomaru T, Katano Toki A, et al. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Endocrinology. 2014;155:3459-72 pubmed publisher
Verkerke H, Naylor C, Zabeau L, Tavernier J, Petri W, Marie C. Kinetics of leptin binding to the Q223R leptin receptor. PLoS ONE. 2014;9:e94843 pubmed publisher
Briggs D, Lockie S, Benzler J, Wu Q, Stark R, Reichenbach A, et al. Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice. Endocrinology. 2014;155:2411-22 pubmed publisher
Han Y, Kang G, Byun K, Ko H, Kim J, Shin M, et al. Leptin-promoted cilia assembly is critical for normal energy balance. J Clin Invest. 2014;124:2193-7 pubmed publisher
Yuan M, Huang G, Li J, Zhang J, Li F, Li K, et al. Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process. Reprod Biol Endocrinol. 2014;12:15 pubmed publisher
Hosoi T, Yamaguchi R, Noji K, Matsuo S, Baba S, Toyoda K, et al. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med. 2014;6:335-46 pubmed publisher
Fujita Y, Fujii T, Mimori T, Sato T, Nakamura T, Iwao H, et al. Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice. J Immunol. 2014;192:979-84 pubmed publisher
Moraes Vieira P, Larocca R, Bassi E, Peron J, Andrade Oliveira V, Wasinski F, et al. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol. 2014;44:794-806 pubmed publisher
Gonzalez Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, et al. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013;113:1331-44 pubmed publisher
Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, et al. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology. 2013;154:4525-35 pubmed publisher
Zhang Y, Seo S, Bhattarai S, Bugge K, Searby C, Zhang Q, et al. BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Hum Mol Genet. 2014;23:40-51 pubmed publisher
Zheng M, Zhang Q, Joe Y, Kim S, Uddin M, Rhew H, et al. Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress. Am J Physiol Endocrinol Metab. 2013;304:E780-8 pubmed publisher
Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees E, et al. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS ONE. 2012;7:e32700 pubmed publisher
Blouet C, Schwartz G. Nutrient-sensing hypothalamic TXNIP links nutrient excess to energy imbalance in mice. J Neurosci. 2011;31:6019-27 pubmed publisher
Li X, Wu X, Camacho R, Schwartz G, LeRoith D. Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms. PLoS ONE. 2011;6:e17058 pubmed publisher
Shapiro N, Khankin E, van Meurs M, Shih S, Lu S, Yano M, et al. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010;185:517-24 pubmed publisher
Kim K, Yoon Y, Lee H, Yoon S, Kim S, Shin S, et al. Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. J Biol Chem. 2010;285:8905-17 pubmed publisher
Unger E, Piper M, Olofsson L, Xu A. Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology. 2010;151:671-82 pubmed publisher
Pini M, Fantuzzi G. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J Leukoc Biol. 2010;87:51-8 pubmed publisher
Gruver A, Ventevogel M, Sempowski G. Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. J Endocrinol. 2009;203:75-85 pubmed publisher
Neels J, Badeanlou L, Hester K, Samad F. Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis. J Biol Chem. 2009;284:20692-8 pubmed publisher
Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S. Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. Biochem Biophys Res Commun. 2009;384:311-5 pubmed publisher
Narvekar P, Berriel Diaz M, Krones Herzig A, Hardeland U, Strzoda D, Stöhr S, et al. Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice. Diabetes. 2009;58:1040-9 pubmed publisher
Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, et al. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury. Lab Invest. 2009;89:222-30 pubmed publisher
Zhang W, Della Fera M, Hartzell D, Hausman D, Baile C. Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life Sci. 2008;83:35-42 pubmed publisher
Fenton J, Birmingham J, Hursting S, Hord N. Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells. Int J Cancer. 2008;122:2437-45 pubmed publisher
Yu I, Lin H, Liu N, Wang R, Sparks J, Yeh S, et al. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology. 2008;149:2361-8 pubmed publisher
Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart J, et al. FXR-deficiency confers increased susceptibility to torpor. FEBS Lett. 2007;581:5191-8 pubmed
Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, et al. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. Am J Physiol Heart Circ Physiol. 2007;292:H2387-96 pubmed
Xu A, Ste Marie L, Kaelin C, Barsh G. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007;148:72-80 pubmed
Raju S, Zheng M, Schuleri K, Phan A, Bedja D, Saraiva R, et al. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci U S A. 2006;103:4222-7 pubmed
De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti G, Fontana S, et al. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest. 2006;116:447-55 pubmed
Mistrik P, Moreau F, Allen J. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Anal Biochem. 2004;327:271-7 pubmed
Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, et al. Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice. J Am Soc Nephrol. 2004;15:645-9 pubmed
Kveiborg M, Chiusaroli R, Sims N, Wu M, Sabatakos G, Horne W, et al. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels. Endocrinology. 2002;143:4304-9 pubmed
Kaser S, Kaser A, Vogel W, Patsch J, Tilg H. Interferon-alpha suppresses leptin levels: studies in interferon-alpha treated patients with hepatitis C virus infection and murine adipocytes. Eur Cytokine Netw. 2002;13:225-9 pubmed
Matarese G, Sanna V, Lechler R, Sarvetnick N, Fontana S, Zappacosta S, et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002;51:1356-61 pubmed
Lin S, Thomas T, Storlien L, Huang X. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord. 2000;24:639-46 pubmed
product information
brand :
R&D Systems
master code :
498-OB
SKU :
498-OB-01M
product name :
Recombinant Mouse Leptin Protein, CF
unit size :
1 mg
description :
Chemical dimerizer
target :
Leptin/OB
category :
Proteins and Enzymes
alt names :
FLJ94114, LEP, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris-HCl and NaCl.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
16 kDa
gene symbol :
Lep
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human Leptin R. The ED50 for this effect is 0.075-0.45 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q544U0
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse Leptin Protein, CF
USD :
229
Jul-22 :
248 USD
sizes available :
1 mg (also 5 mg)
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.