Recombinant Mouse Leptin R Fc Chimera Protein | R&D Systems 497-LR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Leptin R Fc Chimera Protein

catalog :

497-LR-100

quantity :

100 ug

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Song N, Lee A, Yasmeen R, Shen Q, Yang K, Kumar S, et al. Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity. Cells. 2022;11: pubmed publisher
Kuehm L, Khojandi N, Piening A, Klevorn L, Geraud S, McLaughlin N, et al. Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy. Cancer Immunol Res. 2021;9:227-238 pubmed publisher
Lee C, Song D, Park C, Choi J, Kang G, Shin S, et al. Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus. Nat Commun. 2020;11:5772 pubmed publisher
Reis B, Lee K, Fanok M, Mascaraque C, Amoury M, Cohn L, et al. Leptin receptor signaling in T cells is required for Th17 differentiation. J Immunol. 2015;194:5253-60 pubmed publisher
Shapiro N, Khankin E, van Meurs M, Shih S, Lu S, Yano M, et al. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010;185:517-24 pubmed publisher
Tu H, Kastin A, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. J Cell Physiol. 2008;214:301-5 pubmed
Cohen S, Kokkotou E, Biddinger S, Kondo T, Gebhardt R, Kratzsch J, et al. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007;282:23672-8 pubmed
De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti G, Fontana S, et al. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest. 2006;116:447-55 pubmed
Mistrik P, Moreau F, Allen J. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Anal Biochem. 2004;327:271-7 pubmed
Dobrzanski P, Hunter K, Jones Bolin S, Chang H, Robinson C, Pritchard S, et al. Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist. Cancer Res. 2004;64:910-9 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

497-LR

SKU :

497-LR-100

product name :

Recombinant Mouse Leptin R Fc Chimera Protein

Description :

The Recombinant Mouse Leptin R Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Mouse Leptin R Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

Leptin R

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES, NaCl and CHAPS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

150-170 kDa, reducing conditions

theoretical molecular weight :

120 kDa (monomer)

gene symbol :

Lepr

details of functionality :

Measured by its ability to inhibit Leptin-dependent proliferation of BaF3 mouse pro-B cells transfected with human Leptin R. The ED50 for this effect is 0.004-0.015 µg/mL in the presence of 1 ng/mL recombinant mouse Leptin.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q3US58

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Leptin R Fc Chimera Protein

USD :

470 USD

alt names :

B219, CD295, CD295 antigen, DB, DKFZp686B1731, huB219, LEPR, LEP-R, leptin receptor, LeptinR, OB R, OB receptor, OB-R, OBRCD295

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage