Recombinant Human Glyoxalase I Protein, CF | R&D Systems 4959-GL-02M product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Glyoxalase I Protein, CF

catalog :

4959-GL-02M

quantity :

2500 ug

price :

399 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Al Balas Q, Al Smadi M, Hassan M, Al Jabal G, Almaaytah A, Alzoubi K. Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors. Molecules. 2019;24: pubmed publisher
Al Sha er M, Al Balas Q, Hassan M, Al Jabal G, Almaaytah A. Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents. Comput Biol Chem. 2019;80:102-110 pubmed publisher
Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
Jo Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, et al. Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. Aging Cell. 2014;13:519-28 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4959-GL

SKU :

4959-GL-02M

product name :

Recombinant Human Glyoxalase I Protein, CF

Description :

The Recombinant Human Glyoxalase I Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Glyoxalase I Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Glyoxalase I

category :

Proteins and Enzymes

unit size :

2500 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-HCl and DTT.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

25 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

GLO1

details of functionality :

Measured by its ability to catalyze the formation of S -D-lactoylglutathione from the hemimercaptal adduct that forms spontaneously between methylglyoxal and reduced glutathione. The specific activity is 100 nmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_006699

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Human Glyoxalase I Protein

USD :

399 USD

alt names :

Aldoketomutase, EC 4.4.1.5, GLO1, GLOD1, Glx I, GLYI, glyoxalase domain containing 1, glyoxalase Ialdoketomutase, Ketone-aldehyde mutase, lactoyl glutathione lyase, lactoylglutathione lyase, methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage