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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Oncostatin M (OSM) Protein, CF
catalog :
495-MO-025/CF
quantity :
25 ug
price :
336 USD
more info or order :
citations: 60
Reference
Lee S, Karns R, Shin S. Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells. Cell Signal. 2022;100:110458 pubmed publisher
Bailey J, Hang H, Boudreau A, Elks C. Oncostatin M Induces Lipolysis and Suppresses Insulin Response in 3T3-L1 Adipocytes. Int J Mol Sci. 2022;23: pubmed publisher
Valussi M, Besser J, Wystub Lis K, Zukunft S, Richter M, Kubin T, et al. Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart. Sci Adv. 2021;7:eabi6648 pubmed publisher
van Krieken P, Odermatt T, Borsigova M, Bluher M, Wueest S, Konrad D. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling. Mol Metab. 2021;54:101341 pubmed publisher
Anzai K, Tsuruya K, Ida K, Kagawa T, Inagaki Y, Kamiya A. Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts. Sci Rep. 2021;11:18551 pubmed publisher
Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, et al. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nat Commun. 2021;12:3390 pubmed publisher
Zeng J, Jing Y, Wu Q, Zeng J, Wei L, Liu J. Autophagy Is Required for Hepatic Differentiation of Hepatic Progenitor Cells via Wnt Signaling Pathway. Biomed Res Int. 2021;2021:6627506 pubmed publisher
Kwiecien K, Brzoza P, Bak M, Majewski P, Skulimowska I, Bednarczyk K, et al. The methylation status of the chemerin promoter region located from - 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels. Sci Rep. 2020;10:13702 pubmed publisher
Alcala S, Sancho P, Martinelli P, Navarro D, Pedrero C, Martin Hijano L, et al. ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity. Nat Commun. 2020;11:2682 pubmed publisher
Lim J, Choi J, Park E, Choi Y. Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M. Korean J Physiol Pharmacol. 2020;24:203-212 pubmed publisher
Lim J, Choi J, Park E, Choi Y. Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M. Korean J Physiol Pharmacol. 2020;24:203-212 pubmed publisher
Oatley M, Bölükbaşı Ö, Svensson V, Shvartsman M, Ganter K, Zirngibl K, et al. Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition. Nat Commun. 2020;11:586 pubmed publisher
An S, Raju I, Surenkhuu B, Kwon J, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;: pubmed publisher
Simonneau M, Frouin E, Huguier V, Jermidi C, Jégou J, Godet J, et al. Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression. Oncotarget. 2018;9:36457-36473 pubmed publisher
Martínez Fábregas J, Prescott A, van Kasteren S, Pedrioli D, McLean I, Moles A, et al. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018;9:5343 pubmed publisher
van Keulen D, Pouwer M, Pasterkamp G, van Gool A, Sollewijn Gelpke M, Princen H, et al. Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice. PLoS ONE. 2018;13:e0204911 pubmed publisher
Yanagawa T, Sumiyoshi H, Higashi K, Nakao S, Higashiyama R, Fukumitsu H, et al. Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice. Stem Cells. 2019;37:89-101 pubmed publisher
Tawara K, Bolin C, Koncinsky J, Kadaba S, Covert H, Sutherland C, et al. OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung. Breast Cancer Res. 2018;20:53 pubmed publisher
Sampath S, Sampath S, Ho A, Corbel S, Millstone J, Lamb J, et al. Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M. Nat Commun. 2018;9:1531 pubmed publisher
Machiyama T, So T, Okuyama Y, Kobayashi S, Phung H, Asao A, et al. TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation. Biochem Biophys Res Commun. 2018;499:544-550 pubmed publisher
Sin Y, Ballantyne L, Richmond C, Funk C. Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice. Mol Ther Nucleic Acids. 2018;10:122-130 pubmed publisher
Lloyd Lewis B, Krueger C, Sargeant T, D Angelo M, Deery M, Feret R, et al. Stat3-mediated alterations in lysosomal membrane protein composition. J Biol Chem. 2018;293:4244-4261 pubmed publisher
Torossian F, Guerton B, Anginot A, Alexander K, Desterke C, Soave S, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2: pubmed publisher
Richard A, Hang H, Stephens J. Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue. J Biol Chem. 2017;292:19733-19742 pubmed publisher
Jiang X, Hawkins J, Lee J, Lizama C, Bos F, Zape J, et al. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017;8:128 pubmed publisher
Yang M, Arai A, Udagawa N, Hiraga T, Lijuan Z, Ito S, et al. Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. Sci Rep. 2017;7:4928 pubmed publisher
Sin Y, Price P, Ballantyne L, Funk C. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. Sci Rep. 2017;7:2585 pubmed publisher
Pan X, Jing Y, Liu W, Han Z, Li R, Yang Y, et al. Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway. Cell Cycle. 2017;16:1357-1365 pubmed publisher
Kochat V, Equbal Z, Baligar P, Kumar V, Srivastava M, Mukhopadhyay A. JMJD3 aids in reprogramming of bone marrow progenitor cells to hepatic phenotype through epigenetic activation of hepatic transcription factors. PLoS ONE. 2017;12:e0173977 pubmed publisher
Katayama H, Yasuchika K, Miyauchi Y, Kojima H, Yamaoka R, Kawai T, et al. Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon. Sci Rep. 2017;7:44498 pubmed publisher
Tanimizu N, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka T. Progressive induction of hepatocyte progenitor cells in chronically injured liver. Sci Rep. 2017;7:39990 pubmed publisher
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
Laresgoiti U, Nikolić M, Rao C, Brady J, Richardson R, Batchen E, et al. Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016;143:3686-3699 pubmed
Walker E, Johnson R, Hu Y, Brennan H, Poulton I, Zhang J, et al. Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem. 2016;291:21703-21716 pubmed
Tanimizu N, Ichinohe N, Ishii M, Kino J, Mizuguchi T, Hirata K, et al. Liver Progenitors Isolated from Adult Healthy Mouse Liver Efficiently Differentiate to Functional Hepatocytes In Vitro and Repopulate Liver Tissue. Stem Cells. 2016;34:2889-2901 pubmed publisher
Anzai K, Chikada H, Tsuruya K, Ida K, Kagawa T, Inagaki Y, et al. Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture. Sci Rep. 2016;6:28283 pubmed publisher
Elks C, Zhao P, Grant R, Hang H, Bailey J, Burk D, et al. Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo. J Biol Chem. 2016;291:17066-76 pubmed publisher
Kodama T, Newberg J, Kodama M, Rangel R, Yoshihara K, Tien J, et al. Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2016;113:E3384-93 pubmed publisher
Guthrie L, Abiraman K, Plyler E, Sprenkle N, Gibson S, McFarland B, et al. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses. J Biol Chem. 2016;291:15830-40 pubmed publisher
Pohin M, Guesdon W, Mekouo A, Rabeony H, Paris I, Atanassov H, et al. Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation. Eur J Immunol. 2016;46:1737-51 pubmed publisher
Sakamoto K, Wehde B, Yoo K, Kim T, Rajbhandari N, Shin H, et al. Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling. Mol Cell Biol. 2016;36:1673-90 pubmed publisher
Fagoonee S, Famulari E, Silengo L, Tolosano E, Altruda F. Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells. PLoS ONE. 2015;10:e0136762 pubmed publisher
Seto D, Kandarian S, Jackman R. A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem. 2015;290:19976-86 pubmed publisher
Goyden J, Tawara K, Hedeen D, Willey J, Oxford J, Jorcyk C. The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS ONE. 2015;10:e0127230 pubmed publisher
Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, et al. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol. 2014;34:3911-25 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, et al. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine. 2014;68:101-9 pubmed publisher
Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, et al. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014;34:1976-90 pubmed publisher
Sun G, Dong L, An W. Involvement of hepatic stimulator substance in the regulation of hepatoblast maturation into hepatocytes in vitro. Stem Cells Dev. 2014;23:1675-87 pubmed publisher
Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, et al. Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports. 2013;1:545-59 pubmed publisher
Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y. Lack of oncostatin M receptor ? leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J Biol Chem. 2013;288:21861-75 pubmed publisher
Nicolaidou V, Wong M, Redpath A, Ersek A, Baban D, Williams L, et al. Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS ONE. 2012;7:e39871 pubmed publisher
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C. Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. J Biol Chem. 2011;286:34271-85 pubmed publisher
Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
Jung I, Noh K, Lee C, Chun S, Jeong S, Park J, et al. Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem Biophys Res Commun. 2010;394:272-8 pubmed publisher
Brounais B, David E, Chipoy C, Trichet V, Ferre V, Charrier C, et al. Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells. Bone. 2009;44:830-9 pubmed publisher
Sugaya M, Fang L, Cardones A, Kakinuma T, Jaber S, Blauvelt A, et al. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J Immunol. 2006;177:7665-72 pubmed
Gard A, Gavin E, Solodushko V, Pennica D. Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience. 2004;127:43-52 pubmed
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M. The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch Dermatol Res. 2001;293:508-14 pubmed
product information
master code :
495-MO/CF
SKU :
495-MO-025/CF
product name :
Recombinant Mouse Oncostatin M (OSM) Protein, CF
unit size :
25 ug
description :
The Recombinant Mouse Oncostatin M (OSM) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Oncostatin M (OSM) Protein, CF has been validated for the following applications: Bioactivity.
target :
Oncostatin M/OSM
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
theoretical molecular weight :
21 kDa
gene symbol :
Osm
details of functionality :
Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P53347.1
applications :
Bioactivity
source long :
E. coli -derived mouse Oncostatin M/OSM protein Ala24-Arg206, with an N-terminal Met
source short :
E. coli
USD :
336 USD
alt names :
MGC20461, oncostatin M, oncostatin-M
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.