Recombinant Human Activin AC Heterodimer Protein | R&D Systems 4879-AC-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin AC Heterodimer Protein

catalog :

4879-AC-010

quantity :

10 ug

price :

463 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Olsen O, Hella H, Elsaadi S, Jacobi C, Martinez Hackert E, Holien T. Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors. Biomolecules. 2020;10: pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4879-AC

SKU :

4879-AC-010

product name :

Recombinant Human Activin AC Heterodimer Protein

Description :

The Recombinant Human Activin AC Heterodimer Protein from R&D Systems is derived from CHO. The Recombinant Human Activin AC Heterodimer Protein has been validated for the following applications: Binding Activity.

target :

Activin AC

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in HCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

23 kDa, reducing conditions

theoretical molecular weight :

12.9 kDa ( beta A subunit), 12.5 kDa ( beta C subunit)

details of functionality :

Measured by its binding ability in a functional ELISA. In a 100 µL reaction mixture containing rhActivin AC at 2 nM and rhActivin RIIB/Fc Chimera dilutions at 0.02-41 nM, the concentration of rhActivin RIIB/Fc Chimera (Catalog # 339-RBB) that produces 50% of the optimal binding response is found to be approximately 0.8-4 nM.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_002183 ( beta A) NP_005529 ( beta C)

applications :

Binding Activity

source :

CHO-derived Recombinant Human Activin AC Heterodimer Protein

USD :

463 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage