Recombinant Mouse IL-1ra/IL-1F3 Protein | R&D Systems 480-RM-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-1ra/IL-1F3 Protein

catalog :

480-RM-010

quantity :

10 ug (also 50 ug)

price :

385 USD

citations: 33

Reference
Wang J, Yu H, Li X, Li F, Chen H, Zhang X, et al. A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice. Brain Behav Immun. 2024;119:56-83 pubmed publisher
Goks xf8 yr L, Funch A, Okholm A, Theander T, de Jongh W, Bonefeld C, et al. Preclinical Efficacy of a Capsid Virus-like Particle-Based Vaccine Targeting IL-1β for Treatment of Allergic Contact Dermatitis. Vaccines (Basel). 2022;10: pubmed publisher
McMurray K, Winter A, Ahlbrand R, Wilson A, Shukla S, Sah R. Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice. Brain Behav Immun. 2022;101:304-317 pubmed publisher
Takahashi A, Aleyasin H, Stavarache M, Li L, Cathomas F, Parise L, et al. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Mol Psychiatry. 2021;: pubmed publisher
Namai F, Shigemori S, Ogita T, Sato T, Shimosato T. Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice. Exp Mol Med. 2020;52:1627-1636 pubmed publisher
Dong Y, Li S, Lu Y, Li X, Liao Y, Peng Z, et al. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. J Neuroinflammation. 2020;17:205 pubmed publisher
Julier Z, Karami R, Nayer B, Lu Y, Park A, Maruyama K, et al. Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling. Sci Adv. 2020;6:eaba7602 pubmed publisher
Pan P, Zhang Q, Liu W, Wang W, Yu Z, Lao Z, et al. Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage. Front Microbiol. 2019;10:2637 pubmed publisher
Mirabelli E, Ni L, Li L, Acioglu C, Heary R, Elkabes S. Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2). J Neuroinflammation. 2019;16:207 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Xiang H, Lin L, Hu X, Zhu H, Li H, Zhang R, et al. AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression. J Neuroinflammation. 2019;16:34 pubmed publisher
Kang Y, Zhang H, Zhao Y, Wang Y, Wang W, He Y, et al. Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis. Cell Rep. 2018;22:3493-3506 pubmed publisher
Li M, Zheng H, Luo Y, He J, Wang W, Han J, et al. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs. Mol Psychiatry. 2018;23:556-568 pubmed publisher
Gentile A, Fresegna D, Musella A, Sepman H, Bullitta S, De Vito F, et al. Interaction between interleukin-1Î² and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2016;13:231 pubmed publisher
Reed M, Morris S, Owczarczyk A, Lukacs N. Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1. Mucosal Immunol. 2015;8:1118-30 pubmed publisher
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFÎ² signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher
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Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, et al. Interleukin-1Î² causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener. 2014;9:56 pubmed publisher
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product information

master code :

480-RM

SKU :

480-RM-010

product name :

Recombinant Mouse IL-1ra/IL-1F3 Protein

unit size :

10 ug (also 50 ug)

description :

The Recombinant Mouse IL-1ra/IL-1F3 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse IL-1ra/IL-1F3 Protein has been validated for the following applications: Bioactivity.

target :

IL-1ra/IL-1F3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Citric Acid, NaCl and EDTA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

theoretical molecular weight :

17 kDa

gene symbol :

Il1rn

details of functionality :

Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 15-60 ng/mL in the presence of 50 pg/mL of recombinant human IL-1 alpha .

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q542W1

applications :

Bioactivity

source long :

E. coli -derived mouse IL-1ra/IL-1F3 protein Arg8-Gln159, with an N-terminal Met

source short :

E. coli

USD :

385 USD

alt names :

DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4

storage :

12 months from date of receipt, <= -20 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, <= -20 ░C under sterile conditions after reconstitution.