Recombinant Mouse IL-1ra/IL-1F3 Protein, CF | R&D Systems 480-RM-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-1ra/IL-1F3 Protein, CF

catalog :

480-RM-010/CF

quantity :

10 ug

price :

345 USD

more info or order :

R&D Systems product webpage

citations: 26

Reference
Takahashi A, Aleyasin H, Stavarache M, Li L, Cathomas F, Parise L, et al. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Mol Psychiatry. 2021;: pubmed publisher
Namai F, Shigemori S, Ogita T, Sato T, Shimosato T. Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice. Exp Mol Med. 2020;52:1627-1636 pubmed publisher
Dong Y, Li S, Lu Y, Li X, Liao Y, Peng Z, et al. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice. J Neuroinflammation. 2020;17:205 pubmed publisher
Pan P, Zhang Q, Liu W, Wang W, Yu Z, Lao Z, et al. Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage. Front Microbiol. 2019;10:2637 pubmed publisher
Mirabelli E, Ni L, Li L, Acioglu C, Heary R, Elkabes S. Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2). J Neuroinflammation. 2019;16:207 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Xiang H, Lin L, Hu X, Zhu H, Li H, Zhang R, et al. AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression. J Neuroinflammation. 2019;16:34 pubmed publisher
Kang Y, Zhang H, Zhao Y, Wang Y, Wang W, He Y, et al. Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis. Cell Rep. 2018;22:3493-3506 pubmed publisher
Li M, Zheng H, Luo Y, He J, Wang W, Han J, et al. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs. Mol Psychiatry. 2018;23:556-568 pubmed publisher
Gentile A, Fresegna D, Musella A, Sepman H, Bullitta S, De Vito F, et al. Interaction between interleukin-1Î² and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2016;13:231 pubmed publisher
Reed M, Morris S, Owczarczyk A, Lukacs N. Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1. Mucosal Immunol. 2015;8:1118-30 pubmed publisher
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFÎ² signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher
Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W. Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. MBio. 2015;6: pubmed publisher
Khare S, Ratsimandresy R, de Almeida L, Cuda C, Rellick S, Misharin A, et al. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol. 2014;15:343-53 pubmed publisher
Zhao H, Zhao X, Cao X, Wu G. Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice. Immun Ageing. 2012;9:12 pubmed publisher
Koo J, Russo S, Ferguson D, Nestler E, Duman R. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A. 2010;107:2669-74 pubmed publisher
Osuchowski M, Connett J, Welch K, Granger J, Remick D. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit Care Med. 2009;37:1567-73 pubmed publisher
Abraham J, Johnson R. Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav Immun. 2009;23:396-401 pubmed publisher
Ortiz L, DuTreil M, Fattman C, Pandey A, Torres G, Go K, et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A. 2007;104:11002-7 pubmed
Taki N, Tatro J, Lowe R, Goldberg V, Greenfield E. Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone. 2007;40:1276-83 pubmed
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product information

brand :

R&D Systems

master code :

480-RM/CF

SKU :

480-RM-010/CF

product name :

Recombinant Mouse IL-1ra/IL-1F3 Protein, CF

unit size :

10 ug

target :

IL-1ra/IL-1F3

category :

Proteins and Enzymes

alt names :

DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4

buffer :

Lyophilized from a 0.2 µm filtered solution in Citric Acid, NaCl and EDTA.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

storage :

12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.

theoretical molecular weight :

17 kDa

gene symbol :

Il1rn

details of functionality :

Measured by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. et al . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 272. The ED50 for this effect is 15-60 ng/mL in the presence of 50 pg/mL of Recombinant Human IL-1 alpha/IL-1F1 (Catalog # 200-LA ).

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q542W1

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse IL-1ra/IL-1F3 Protein, CF

USD :

319

Jul-22 :

345 USD

sizes available :

10 ug (also 50 ug)

more info or order :

R&D Systems product webpage