product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse CCL2/JE/MCP-1 Protein, CF
catalog :
479-JE-010/CF
quantity :
10 ug (also 50 ug)
price :
277 USD
more info or order :
citations: 92
Reference
Pajulas A, Fu Y, Cheung C, Chu M, Cannon A, Alakhras N, et al. Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation. Mucosal Immunol. 2023;16:432-445 pubmed publisher
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, et al. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. PLoS ONE. 2023;18:e0280590 pubmed publisher
Liu J, Cheng Y, Zhang X, Chen Y, Zhu H, Chen K, et al. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity. Cell Rep. 2023;42:111991 pubmed publisher
Choi H, Park S, Choi Y, Kim S, Kwag E, Song S, et al. Selective Immune Modulating Activities of Viscum album and Its Components; A Possibility of Therapeutics on Skin Rash Induced by EGFR Inhibitors. Integr Cancer Ther. 2022;21:15347354221118332 pubmed publisher
Rajesh A, Droho S, Lavine J. Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease. J Neuroinflammation. 2022;19:203 pubmed publisher
Brennan F, Li Y, Wang C, Ma A, Guo Q, Li Y, et al. Microglia coordinate cellular interactions during spinal cord repair in mice. Nat Commun. 2022;13:4096 pubmed publisher
Itakura M, Yamaguchi K, Kitazawa R, Lim S, Anan Y, Yoshitake J, et al. Histone functions as a cell-surface receptor for AGEs. Nat Commun. 2022;13:2974 pubmed publisher
Ye L, Jin K, Liao Z, Xiao Z, Xu H, Lin X, et al. Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer. EBioMedicine. 2022;79:104016 pubmed publisher
Ahn Y, Wang L, Tavakoli S, Nguyen H, Short J, Asmis R. Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner. Nat Commun. 2022;13:790 pubmed publisher
Fan Y, Hsu K, Lin T, Zechner D, Hsu S, Tsai Y. Investigation of Anti-Tumor Effects of an MLK1 Inhibitor in Prostate and Pancreatic Cancers. Biology (Basel). 2021;10: pubmed publisher
Lima L, Ham S, Shin H, Chai E, Lek E, Lobb R, et al. Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nat Commun. 2021;12:3543 pubmed publisher
Ishihara S, Obeidat A, Wokosin D, Ren D, Miller R, Malfait A, et al. The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice. Arthritis Res Ther. 2021;23:103 pubmed publisher
Maria Z, Turner E, Agasing A, Kumar G, Axtell R. Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE. Int J Mol Sci. 2021;22: pubmed publisher
Villarreal Ponce A, Tiruneh M, Lee J, Guerrero Juarez C, Kuhn J, David J, et al. Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair. Cell Rep. 2020;33:108417 pubmed publisher
Popiolek Barczyk K, Ciechanowska A, Ciapała K, Pawlik K, Oggioni M, Mercurio D, et al. The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury, and CCL2 modulates the complement system in microglia. Mol Cell Probes. 2020;54:101671 pubmed publisher
Wang L, Wang S, Shi Y, Li R, Günther S, Ong Y, et al. YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 2020;11:5455 pubmed publisher
Wang K, Gu Y, Liao Y, Bang S, Donnelly C, Chen O, et al. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. J Clin Invest. 2020;130:3603-3620 pubmed publisher
Jerebtsova M, Ahmad A, Kumari N, Rutagarama O, Nekhai S. Macrophage HIV-1 Gene Expression and Delay Resolution of Inflammation in HIV-Tg Mice. Viruses. 2020;12: pubmed publisher
Jerebtsova M, Ahmad A, Niu X, Rutagarama O, Nekhai S. HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes' Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice. Viruses. 2020;12: pubmed publisher
Kitchen G, Cunningham P, Poolman T, Iqbal M, Maidstone R, Baxter M, et al. The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia. Proc Natl Acad Sci U S A. 2020;117:1543-1551 pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
Kwiatkowski K, Popiolek Barczyk K, Piotrowska A, Rojewska E, Ciapała K, Makuch W, et al. Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia. Cytokine. 2019;119:202-213 pubmed publisher
Qiu M, Huang K, Liu Y, Yang Y, Tang H, Liu X, et al. Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunol. 2019;: pubmed publisher
Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, et al. Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promotes B-ALL Progression by Modulating CCL2 in Leukemia Cells. Cell Rep. 2019;26:1533-1543.e4 pubmed publisher
Silva P, Lauretti Ferreira F, Caldas de Lima M, Lima S, Covarrubias A, De Franco M, et al. Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines. BMC Microbiol. 2019;19:4 pubmed publisher
Kubota T, Inoue M, Kubota N, Takamoto I, Mineyama T, Iwayama K, et al. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 2018;9:4863 pubmed publisher
Lee S, Kong J, You S, Kwon H, Yoo S, Cho C, et al. Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2. J Immunol. 2018;201:359-370 pubmed publisher
Zou A, Magee N, Deng F, Lehn S, Zhong C, Zhang Y. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. J Biol Chem. 2018;293:8656-8671 pubmed publisher
Guo J, Qiu X, Zhang L, Wei R. Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways. Mol Immunol. 2018;97:20-26 pubmed publisher
Johnson V, Webb T, Norman A, Coy J, Kurihara J, Regan D, et al. Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections. Sci Rep. 2017;7:9575 pubmed publisher
Freitas C, Wittner M, Nguyen J, Rondeau V, Biajoux V, Aknin M, et al. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization. J Exp Med. 2017;214:2023-2040 pubmed publisher
Hosaka K, Rojas K, Fazal H, Schneider M, Shores J, Federico V, et al. Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing. Stroke. 2017;48:1052-1060 pubmed publisher
Zhang Y, Wei Y, Jiang B, Chen L, Bai H, Zhu X, et al. Scavenger Receptor A1 Prevents Metastasis of Non-Small Cell Lung Cancer via Suppression of Macrophage Serum Amyloid A1. Cancer Res. 2017;77:1586-1598 pubmed publisher
Nakano H, Lyons Cohen M, Whitehead G, Nakano K, Cook D. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung. J Leukoc Biol. 2017;101:1143-1153 pubmed publisher
Lavender N, Yang J, Chen S, Sai J, Johnson C, Owens P, et al. The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo. BMC Cancer. 2017;17:88 pubmed publisher
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher
Swiecki M, Miller H, Sesti Costa R, Cella M, Gilfillan S, Colonna M. Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state. Mucosal Immunol. 2017;10:936-945 pubmed publisher
Lin C, von der Thusen J, Isermann B, Weiler H, van der Poll T, Borensztajn K, et al. High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis. J Cell Mol Med. 2016;20:2029-2035 pubmed publisher
Zuchtriegel G, Uhl B, Puhr Westerheide D, Pörnbacher M, Lauber K, Krombach F, et al. Platelets Guide Leukocytes to Their Sites of Extravasation. PLoS Biol. 2016;14:e1002459 pubmed publisher
Wang T, Wang Z, Yang P, Xia L, Zhou M, Wang S, et al. PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice. Cell Death Dis. 2016;7:e2176 pubmed publisher
Baek J, Zeng R, Weinmann Menke J, Valerius M, Wada Y, Ajay A, et al. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest. 2015;125:3198-214 pubmed publisher
Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, et al. Murine IL-17+ Vγ4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis. BMC Immunol. 2015;16:36 pubmed publisher
Eguchi A, Mulya A, Lazic M, Radhakrishnan D, Berk M, Povero D, et al. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration. PLoS ONE. 2015;10:e0123110 pubmed publisher
Viana I, de Almeida M, Lins M, Dos Santos Reis M, de Araújo Vieira L, Smaniotto S. Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells. PLoS ONE. 2015;10:e0121249 pubmed publisher
Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, et al. Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014;211:1957-68 pubmed publisher
Chen D, Goswami C, Burnett R, Anjanappa M, Bhat Nakshatri P, Muller W, et al. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle. Cancer Res. 2014;74:4270-81 pubmed publisher
Menichella D, Abdelhak B, Ren D, Shum A, Frietag C, Miller R. CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy. Mol Pain. 2014;10:42 pubmed publisher
Fleetwood A, Achuthan A, Schultz H, Nansen A, Almholt K, Usher P, et al. Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion. J Immunol. 2014;192:3540-7 pubmed publisher
Ramkhelawon B, Hennessy E, Ménager M, Ray T, Sheedy F, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014;20:377-84 pubmed publisher
Sato S, Zhang X. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clin Exp Immunol. 2014;177:102-9 pubmed publisher
Kallis Y, Scotton C, Mackinnon A, Goldin R, Wright N, Iredale J, et al. Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PLoS ONE. 2014;9:e86241 pubmed publisher
Bowcutt R, Bramhall M, Logunova L, Wilson J, Booth C, Carding S, et al. A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection. Mucosal Immunol. 2014;7:1094-105 pubmed publisher
Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, et al. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Stem Cells. 2014;32:1347-60 pubmed publisher
Temme S, Jacoby C, Ding Z, Bönner F, Borg N, Schrader J, et al. Technical advance: monitoring the trafficking of neutrophil granulocytes and monocytes during the course of tissue inflammation by noninvasive 19F MRI. J Leukoc Biol. 2014;95:689-97 pubmed publisher
Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, et al. A circadian clock gene, Rev-erb?, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. J Immunol. 2014;192:407-17 pubmed publisher
Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, et al. Defective TGF-? signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res. 2014;74:471-483 pubmed publisher
Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, et al. Mammalian diaphanous-related formin 1 regulates GSK3?-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE. 2013;8:e80500 pubmed publisher
Zhu X, Zong G, Zhu L, Jiang Y, Ma K, Zhang H, et al. Deletion of class A scavenger receptor deteriorates obesity-induced insulin resistance in adipose tissue. Diabetes. 2014;63:562-77 pubmed publisher
Wanschel A, Seibert T, Hewing B, Ramkhelawon B, Ray T, van Gils J, et al. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention. Arterioscler Thromb Vasc Biol. 2013;33:886-93 pubmed publisher
Kim H, Go H, Akira S, Chung D. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice. J Immunol. 2011;187:4007-17 pubmed publisher
Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael Ainin M, et al. Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol. 2011;179:83-91 pubmed publisher
Russo R, Garcia C, Barcelos L, Rachid M, Guabiraba R, Roffe E, et al. Phosphoinositide 3-kinase ? plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J Leukoc Biol. 2011;89:269-82 pubmed publisher
Koth L, Cambier C, Ellwanger A, Solon M, Hou L, Lanier L, et al. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010;184:6522-8 pubmed publisher
Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M. An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice. Endocrinology. 2010;151:971-9 pubmed publisher
Fujimoto H, Sangai T, Ishii G, Ikehara A, Nagashima T, Miyazaki M, et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer. 2009;125:1276-84 pubmed publisher
Lafdil F, Chobert M, Deveaux V, Zafrani E, Mavier P, Nakano T, et al. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. J Hepatol. 2009;51:55-66 pubmed publisher
Gao Y, Zhang L, Samad O, Suter M, Yasuhiko K, Xu Z, et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci. 2009;29:4096-108 pubmed publisher
Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
Shojaei F, Wu X, ZHONG C, Yu L, Liang X, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature. 2007;450:825-31 pubmed
Penido C, Costa M, Souza M, Costa K, Candea A, Benjamim C, et al. Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway. Int Immunol. 2008;20:129-39 pubmed
Kang J, Kim C, Han I, Kawada T, Yu R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett. 2007;581:4389-96 pubmed
Das R, Burke T, Plow E. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763-72 pubmed
Hollingsworth J, Li Z, Brass D, Garantziotis S, Timberlake S, Kim A, et al. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. 2007;37:248-53 pubmed
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, et al. High pressure promotes monocyte adhesion to the vascular wall. Circ Res. 2007;100:1226-33 pubmed
Yamauchi L, Aliberti J, Baruffi M, Portela R, Rossi M, Gazzinelli R, et al. The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis. Microbes Infect. 2007;9:111-8 pubmed
Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, et al. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J Clin Invest. 2006;116:2105-14 pubmed
Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
Rhodes K, Raivich G, Fawcett J. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience. 2006;140:87-100 pubmed
Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
Ellaban E, Bolgos G, Remick D. Selective macrophage suppression during sepsis. Cell Immunol. 2004;231:103-11 pubmed
Sergejeva S, Ivanov S, Lotvall J, Linden A. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am J Respir Cell Mol Biol. 2005;33:248-53 pubmed
Mbebi C, Gonzalez de Aguilar J, See V, Dupuis L, Frossard N, Mercken L, et al. Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons. Neurobiol Dis. 2005;19:129-41 pubmed
Perrin F, Lacroix S, Avilés Trigueros M, David S. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain. 2005;128:854-66 pubmed
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood. 2005;105:31-9 pubmed
Bengtsson A, Ryan E, Giordano D, Magaletti D, Clark E. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood. 2004;104:1404-10 pubmed
Russell T, Yan Q, Fan G, Khalifah A, Bishop D, Brody S, et al. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1. J Immunol. 2003;171:6866-74 pubmed
Penido C, Vieira de Abreu A, Bozza M, Castro Faria Neto H, Bozza P. Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin. J Immunol. 2003;171:6788-94 pubmed
Bruemmer D, Collins A, Noh G, Wang W, Territo M, Arias Magallona S, et al. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest. 2003;112:1318-31 pubmed
Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, et al. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol. 2003;170:1452-61 pubmed
Neumark E, Cohn M, Lukanidin E, Witz I, Ben Baruch A. Possible co-regulation of genes associated with enhanced progression of mammary adenocarcinomas. Immunol Lett. 2002;82:111-21 pubmed
Maus U, Koay M, Delbeck T, Mack M, Ermert M, Ermert L, et al. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1245-52 pubmed
image
image 1 :
R&D Systems 479-JE-010/CF image 1
Recombinant Mouse CCL2/JE/MCP-1 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
479-JE/CF
SKU :
479-JE-010/CF
product name :
Recombinant Mouse CCL2/JE/MCP-1 Protein, CF
description :
The Recombinant Mouse CCL2/JE/MCP-1 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse CCL2/JE/MCP-1 Protein, CF has been validated for the following applications: Bioactivity.
target :
CCL2/JE/MCP-1
unit size :
10 ug (also 50 ug)
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
8.5 kDa
gene symbol :
Ccl2
details of functionality :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A. The ED50 for this effect is 2-10 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q5SVU3
applications :
Bioactivity
product keywords :
479-JE, rmCCL2/JE, mCCL2, carrier-free, carrier free, 479JE/CF, MCP1, CCL 2, Chemokines, Chemokine, cytokine, cytokines, C-C Motif Chemokine Ligand 2, Monocyte Chemotactic And Activating Factor, Monocyte Secretory Protein JE, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2, Monocyte Chemoattractant Protein-1,
source :
E. coli-derived Recombinant Mouse CCL2/JE/MCP-1 Protein, CF
USD :
271
USD 2025 :
277 USD
alt names :
C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.