Recombinant Mouse CCL5/RANTES Protein | R&D Systems 478-MR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CCL5/RANTES Protein

catalog :

478-MR-025

quantity :

25 ug

price :

365 USD

more info or order :

R&D Systems product webpage

citations: 20

Reference
Lin J, Xu Y, Guo P, Chen Y, Zhou J, Xia M, et al. CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice. J Transl Med. 2023;21:196 pubmed publisher
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, et al. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. PLoS ONE. 2023;18:e0280590 pubmed publisher
Ho M, Yen C, Hsieh T, Kao T, Chiu J, Chiang Y, et al. CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury. Redox Biol. 2021;46:102067 pubmed publisher
Ajoy R, Lo Y, Ho M, Chen Y, Wang Y, Chen Y, et al. CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation. Mol Psychiatry. 2021;26:6451-6468 pubmed publisher
Lin Y, Chen Y, Feng W, Hua R, Zhang J, Huo Y, et al. Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration. Cell Death Dis. 2021;12:273 pubmed publisher
Sharif S, Ueda N, Nakatani Y, Wise L, Clifton S, Lateef Z, et al. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity. Front Microbiol. 2019;10:1421 pubmed publisher
Böttcher J, Bonavita E, Chakravarty P, Blees H, Cabeza Cabrerizo M, Sammicheli S, et al. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control. Cell. 2018;172:1022-1037.e14 pubmed publisher
Lee J, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, et al. The HIV co-receptor CCR5 regulates osteoclast function. Nat Commun. 2017;8:2226 pubmed publisher
Suffee N, Le Visage C, Hlawaty H, Aid Launais R, Vanneaux V, Larghero J, et al. Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy. Sci Rep. 2017;7:13294 pubmed publisher
Pan Y, Smithson L, Ma Y, Hambardzumyan D, Gutmann D. Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Oncotarget. 2017;8:32977-32989 pubmed publisher
Huang S, Walker C, Pennock J, Else K, Muller W, Daniels M, et al. P2X7 receptor-dependent tuning of gut epithelial responses to infection. Immunol Cell Biol. 2017;95:178-188 pubmed publisher
Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, et al. Murine IL-17+ VÎ³4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis. BMC Immunol. 2015;16:36 pubmed publisher
Sottnik J, Dai J, Zhang H, Campbell B, Keller E. Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Cancer Res. 2015;75:2151-8 pubmed publisher
Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, et al. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015;125:1620-36 pubmed publisher
Sato S, Zhang X. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clin Exp Immunol. 2014;177:102-9 pubmed publisher
Kimura K, Nagano M, Salazar G, Yamashita T, Tsuboi I, Mishima H, et al. The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions. Stem Cells Dev. 2014;23:488-501 pubmed publisher
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, et al. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 2013;28:2070-80 pubmed publisher
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
Binder N, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig T, et al. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med. 2009;15:417-24 pubmed publisher
Chou S, Weng J, Lai H, Liao F, Sun S, Tu P, et al. Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J Neurosci. 2008;28:3277-90 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

478-MR

SKU :

478-MR-025

product name :

Recombinant Mouse CCL5/RANTES Protein

Description :

The Recombinant Mouse CCL5/RANTES Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CCL5/RANTES Protein has been validated for the following applications: Bioactivity.

target :

CCL5/RANTES

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

theoretical molecular weight :

7.9 kDa

gene symbol :

Ccl5

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 1.5-9 ng/mL. Measured by its ability to chemoattract 2-day cultured human monocytes. The ED50 for this effect is 30-100 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q5XZF2

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse CCL5/RANTES Protein

USD :

365 USD

alt names :

chemokine (C-C motif) ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage