Recombinant Human Hepsin Protein, CF | R&D Systems 4776-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Hepsin Protein, CF

catalog :

4776-SE-010

quantity :

10 ug

price :

388 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Peñas Martínez J, Luengo Gil G, Espín S, Bohdan N, Ortega Sabater C, Ródenas M, et al. Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells. Biomedicines. 2021;9: pubmed publisher
Kwon H, Ha H, Jeon H, Jang J, Son S, Lee K, et al. Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres. Bioorg Chem. 2021;107:104521 pubmed publisher
Kim K, Kwon H, Choi D, Lim T, Minn I, Son S, et al. Design and synthesis of dye-conjugated hepsin inhibitors. Bioorg Chem. 2019;89:102990 pubmed publisher
Pant S, Mukonoweshuro A, Desai B, Ramjee M, Selway C, Tarver G, et al. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018;61:4335-4347 pubmed publisher
Tervonen T, BelitÅ¡kin D, Pant S, Englund J, Marques E, Ala Hongisto H, et al. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2016;35:1832-46 pubmed publisher

product information

brand :

R&D Systems

master code :

4776-SE

SKU :

4776-SE-010

product name :

Recombinant Human Hepsin Protein, CF

unit size :

10 ug

description :

Positive allosteric modulator of GLP-1 receptors

target :

Hepsin

category :

Proteins and Enzymes

alt names :

EC 3.4.21, EC 3.4.21.106, hepsin, HPN, serine protease hepsin, serine protease hepsin catalytic chain, TMPRSS1, TMPRSS1serine protease hepsin non-catalytic chain, Transmembrane protease serine 1, transmembrane protease, serine 1

buffer :

Supplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.

observed molecular weight :

40-43 kDa, reducing conditions

theoretical molecular weight :

42 kDa

gene symbol :

HPN

details of functionality :

Measured by its ability to cleave tert -butoxycarbonyl-Gln-Arg-Arg-7-amino-4-methylcoumarin (Boc-QRR-AMC). The specific activity is 20,000 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P05981

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human Hepsin Protein, CF

USD :

359

Jul-22 :

388 USD

sizes available :

10 ug

more info or order :

R&D Systems product webpage