Recombinant Human Hepsin Protein, CF | R&D Systems 4776-SE-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Hepsin Protein, CF

catalog :

4776-SE-010

quantity :

10 ug

price :

432 USD

citations: 5

Reference
Peñas Martínez J, Luengo Gil G, Espín S, Bohdan N, Ortega Sabater C, Ródenas M, et al. Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells. Biomedicines. 2021;9: pubmed publisher
Kwon H, Ha H, Jeon H, Jang J, Son S, Lee K, et al. Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres. Bioorg Chem. 2021;107:104521 pubmed publisher
Kim K, Kwon H, Choi D, Lim T, Minn I, Son S, et al. Design and synthesis of dye-conjugated hepsin inhibitors. Bioorg Chem. 2019;89:102990 pubmed publisher
Pant S, Mukonoweshuro A, Desai B, Ramjee M, Selway C, Tarver G, et al. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018;61:4335-4347 pubmed publisher
Tervonen T, BelitÅ¡kin D, Pant S, Englund J, Marques E, Ala Hongisto H, et al. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2016;35:1832-46 pubmed publisher

product information

master code :

4776-SE

SKU :

4776-SE-010

product name :

Recombinant Human Hepsin Protein, CF

unit size :

10 ug

description :

The Recombinant Human Hepsin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Hepsin Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Hepsin

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Sodium Acetate and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

40-43 kDa, reducing conditions

theoretical molecular weight :

42 kDa

gene symbol :

HPN

details of functionality :

Measured by its ability to cleave tert -butoxycarbonyl-Gln-Arg-Arg-7-amino-4-methylcoumarin (Boc-QRR-AMC). The specific activity is 20,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P05981

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived human Hepsin protein Arg45-Leu417 (Asp161Glu & Arg162Lys), with a C-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

EC 3.4.21, EC 3.4.21.106, hepsin, HPN, serine protease hepsin, serine protease hepsin catalytic chain, TMPRSS1, TMPRSS1serine protease hepsin non-catalytic chain, Transmembrane protease serine 1, transmembrane protease, serine 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.