Recombinant Mouse Neurturin Protein | R&D Systems 477-MN-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Neurturin Protein

catalog :

477-MN-025

quantity :

25 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Cabrera J, Manivanh R, North B, Leib D. The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection. MBio. 2019;10: pubmed publisher
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, et al. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons. Proc Natl Acad Sci U S A. 2017;114:E2486-E2493 pubmed publisher
Rosato P, Leib D. Neuronal Interferon Signaling Is Required for Protection against Herpes Simplex Virus Replication and Pathogenesis. PLoS Pathog. 2015;11:e1005028 pubmed publisher
Rosato P, Leib D. Intrinsic innate immunity fails to control herpes simplex virus and vesicular stomatitis virus replication in sensory neurons and fibroblasts. J Virol. 2014;88:9991-10001 pubmed publisher
Knox S, Lombaert I, Haddox C, Abrams S, Cotrim A, Wilson A, et al. Parasympathetic stimulation improves epithelial organ regeneration. Nat Commun. 2013;4:1494 pubmed publisher
Malin S, Molliver D, Koerber H, Cornuet P, Frye R, Albers K, et al. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci. 2006;26:8588-99 pubmed
Leitner M, Wang L, Osborne P, Golden J, Milbrandt J, Johnson E. Expression and function of GDNF family ligands and receptors in the carotid body. Exp Neurol. 2005;191 Suppl 1:S68-79 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

477-MN

SKU :

477-MN-025

product name :

Recombinant Mouse Neurturin Protein

description :

The Recombinant Mouse Neurturin Protein from R&D Systems is derived from E. coli. The Recombinant Mouse Neurturin Protein has been validated for the following applications: Bioactivity, Binding Activity.

target :

Neurturin

unit size :

25 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

theoretical molecular weight :

11.7 kDa (monomer)

gene symbol :

Nrtn

details of functionality :

Measured by its ability to support the survival and stimulate neurite outgrowth of dissociated chick embryonic dorsal root ganglia (DRG) neurons. Davies, A.M. (1989) in Neurotrophic Factor Bioassay Using Dissociated Neurons , Nerve Growth Factor. Rush, R.A. (eds): John Willey and Sons, Ltd. 95. The ED50 for this effect is 2-10 ng/mL. Also measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse GFR alpha -2/GDNF R alpha -2 Fc Chimera (Catalog # 429-FR ) at 1 µg/mL can bind Recombinant Mouse Neurturin with an apparent KD 3.0 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P97463.1

applications :

Bioactivity, Binding Activity

product keywords :

477-MN, rmNeurturin, mNeurturin,, 477MN, cytokinegrowthfact, cytokine, cytokines

source :

E. coli-derived Recombinant Mouse Neurturin Protein

USD :

447

USD 2025 :

456 USD

alt names :

neurturin, NRTN, NTN

more info or order :

R&D Systems product webpage