Recombinant Mouse Jagged 2 Fc Chimera Protein, CF | R&D Systems 4748-JG-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Jagged 2 Fc Chimera Protein, CF

catalog :

4748-JG-050

quantity :

50 ug

price :

483 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Batista M, Diniz P, Torres A, Murta D, Lopes da Costa L, Silva E. Notch signaling in mouse blastocyst development and hatching. BMC Dev Biol. 2020;20:9 pubmed publisher
Silkenstedt E, Arenas F, Colom Sanmartí B, Xargay Torrent S, Higashi M, Giró A, et al. Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy. J Exp Clin Cancer Res. 2019;38:446 pubmed publisher
Liu L, Charville G, Cheung T, Yoo B, Santos P, Schroeder M, et al. Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Cell Stem Cell. 2018;23:544-556.e4 pubmed publisher
Varshney S, Stanley P. Notch Ligand Binding Assay Using Flow Cytometry. Bio Protoc. 2017;7: pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4748-JG

SKU :

4748-JG-050

product name :

Recombinant Mouse Jagged 2 Fc Chimera Protein, CF

Description :

The Recombinant Mouse Jagged 2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Jagged 2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Jagged 2

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining

species :

Mouse

observed molecular weight :

160-165 kDa, reducing conditions

theoretical molecular weight :

140.8 kDa (monomer)

gene symbol :

Jag2

details of functionality :

Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.3-1.2 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9QYE5

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Jagged 2 Fc Chimera Protein

USD :

483 USD

alt names :

HJ2, JAG2, jagged 2, Jagged2, protein jagged-2, SER2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage