product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FGF-8a Protein, CF
catalog :
4745-F8-050
quantity :
50 ug
price :
377 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Earley A, Burbulla L, Krainc D, Awatramani R. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons. Sci Rep. 2021;11:22257 pubmed publisher
Inak G, Rybak Wolf A, Lisowski P, Pentimalli T, Jüttner R, Glažar P, et al. Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nat Commun. 2021;12:1929 pubmed publisher
Fernandes H, Patikas N, Foskolou S, Field S, Park J, Byrne M, et al. Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses. Cell Rep. 2020;33:108263 pubmed publisher
Kim J, Yin X, Jhaldiyal A, Khan M, Martin I, Xie Z, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. 2020;27:633-645.e7 pubmed publisher
Stathakos P, Jiménez Moreno N, Crompton L, Nistor P, Badger J, Barbuti P, et al. A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy. 2020;:1-17 pubmed publisher
Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. Sci Rep. 2019;9:8470 pubmed publisher
Siddiqi F, Menzies F, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019;10:1817 pubmed publisher
Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, et al. Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders. Cell Stem Cell. 2017;20:659-674.e9 pubmed publisher
Hartfield E, Yamasaki Mann M, Ribeiro Fernandes H, Vowles J, James W, Cowley S, et al. Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE. 2014;9:e87388 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
Darby S, Murphy T, Thomas H, Robson C, Leung H, Mathers M, et al. Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br J Cancer. 2009;101:1891-9 pubmed publisher
image
image 1 :
R&D Systems 4745-F8-050 image 1
Recombinant Human FGF-8a Protein Bioactivity
product information
brand :
R&D Systems
master code :
4745-F8
SKU :
4745-F8-050
product name :
Recombinant Human FGF-8a Protein, CF
description :
The Recombinant Human FGF-8a Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human FGF-8a Protein, CF has been validated for the following applications: Bioactivity.
target :
FGF-8
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, and EDTA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
theoretical molecular weight :
21 kDa
gene symbol :
FGF8
details of functionality :
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 0.25-1.5 µg/mL in the presence of 10 µg/mL heparin.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_149355
applications :
Bioactivity
source :
E. coli-derived Recombinant Human FGF-8a Protein, CF
USD :
377
USD 2023 :
377 USD
alt names :
AIGF, AIGFKAL6, Androgen-induced growth factor, FGF8, FGF-8, fibroblast growth factor 8, fibroblast growth factor 8 (androgen-induced), HBGF-8, Heparin-binding growth factor 8, MGC149376
storage :
12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.