Recombinant Mouse Matriptase/ST14 Catalytic Domain, CF | R&D Systems 4735-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Matriptase/ST14 Catalytic Domain, CF

catalog :

4735-SE-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Kwon H, Ha H, Jeon H, Jang J, Son S, Lee K, et al. Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres. Bioorg Chem. 2021;107:104521 pubmed publisher
Ozawa S, Matsubayashi M, Nanaura H, Yanagita M, Mori K, Asanuma K, et al. Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury. J Biol Chem. 2020;295:16002-16012 pubmed publisher
Wu C, Lu M, Feng X, Nakato G, Udey M. Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins. Cells. 2020;9: pubmed publisher
Raman K, Trivedi N, Raymond W, Ganesan R, Kirchhofer D, Verghese G, et al. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013;288:10588-98 pubmed publisher
Szabo R, Kosa P, List K, Bugge T. Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol. 2009;174:2015-22 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4735-SE

SKU :

4735-SE-010

product name :

Recombinant Mouse Matriptase/ST14 Catalytic Domain, CF

Description :

The Recombinant Mouse Matriptase/ST14 Catalytic Domain, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Matriptase/ST14 Catalytic Domain, CF has been validated for the following applications: Enzyme Activity.

target :

Matriptase/ST14

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

27 kDa (major) and minor auto-activation fragments, reducing conditions

theoretical molecular weight :

3 kDa 26 kDa

gene symbol :

St14

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC (Catalog # ES014 ). The specific activity is 4,000 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_035306

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Mouse Matriptase/ST14 Catalytic Domain

USD :

423 USD

alt names :

EC 3.4.21, Epithin, HAI, Matriptase, Membrane-type serine protease 1, MTSP1, MT-SP1EC 3.4.21.109, prostamin, PRSS14, Serine protease 14, Serine protease TADG-15, SNC19, SNC19MTSP1, ST14, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin), suppressor of tumorigenicity 14 protein, TADG15, TADG-15, TMPRSS14, tumor associated differentially expressed gene 15 protein, Tumor-associated differentially-expressed gene 15 protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage