Recombinant Mouse Serpin A3N Protein, CF | R&D Systems 4709-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Serpin A3N Protein, CF

catalog :

4709-PI-010

quantity :

10 ug

price :

447 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Kim H, Leng K, Park J, Sorets A, Kim S, Shostak A, et al. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022;13:6581 pubmed publisher
Ho Y, Shimbo T, Wijaya E, Kitayama T, Takaki S, Ikegami K, et al. Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model. Cell Mol Gastroenterol Hepatol. 2021;12:547-566 pubmed publisher
Zhang H, Wang P, Li Y, Bao Y. SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response. Respir Physiol Neurobiol. 2021;288:103642 pubmed publisher
Vicuña L, Strochlic D, Latremoliere A, Bali K, Simonetti M, Husainie D, et al. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015;21:518-23 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

4709-PI

SKU :

4709-PI-010

product name :

Recombinant Mouse Serpin A3N Protein, CF

Description :

The Recombinant Mouse Serpin A3N Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Serpin A3N Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Serpin A3N

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

59 kDa, reducing conditions

theoretical molecular weight :

46 kDa

gene symbol :

Serpina3n

details of functionality :

Measured by its ability to inhibit Granzyme B cleavage of tert -butoxycarbonyl-Ala-Ala-Asp-thiobenzyl ester (Boc-AAD-SBzl). The IC50 is 25 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q91WP6

applications :

Inhibition Activity

source :

NS0-derived Recombinant Mouse Serpin A3N Protein

USD :

447 USD

alt names :

A1A;A1AT;AAT;Alpha-1-antitrypsin;alpha1AT;nNIF;PI;PI1;PRO2275;SERPINA1, Spi2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage